Articles with "mps1 inhibitors" as a keyword



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Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer.

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Published in 2022 at "European journal of medicinal chemistry"

DOI: 10.2139/ssrn.4185504

Abstract: Monopolar spindle kinase 1 (Mps1), a core component of the spindle assembly checkpoint (SAC), plays a crucial role in the transition of cells from mid-to late mitosis. As an attractive therapeutic target, inhibition of Mps1… read more here.

Keywords: treatment; breast cancer; mps1 inhibitors; mps1 ... See more keywords