Pharmacology of mitochondrial permeability transition pore inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21593
Abstract: It is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability transition pores (mPTPs), which changes the permeability of the mitochondria. mPTP… read more here.
Keywords: mptp; permeability; pharmacology; mitochondrial permeability ... See more keywords
An in vivo and in vitro model on the protective effect of cilnidipine on contrast‐induced nephropathy via regulation of apoptosis and CaMKⅡ/mPTP pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23238
Abstract: Contrast‐induced nephropathy (CIN) is an acute kidney injury (AKI) observed after the administration of contrast media. Calcium channel blockers (CCBs) have been reported to exert a renal protective effect. This study aims to investigate the… read more here.
Keywords: cilnidipine; contrast; protective effect; camk ... See more keywords
MPTP Parkinsonism and Implications for Understanding Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13344
Abstract: In 1983, Langston et al first reported chronic parkinsonism in individuals following self-injection of intravenous heroin contaminated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This astute clinical observation and subsequent work led to the discovery of MPTP as a… read more here.
Keywords: mptp; mptp parkinsonism; disease mptp; parkinson disease ... See more keywords
Neurometabolic profiles of the substantia nigra and striatum of MPTP‐intoxicated common marmosets: An in vivo proton MRS study at 9.4 T
Sign Up to like & getrecommendations! Published in 2017 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3686
Abstract: Given the strong coupling between the substantia nigra (SN) and striatum (STR) in the early stage of Parkinson's disease (PD), yet only a few studies reported to date that have simultaneously investigated the neurochemistry of… read more here.
Keywords: mptp; group; mptp weeks; mrs ... See more keywords
Acute MPTP treatment decreases dendritic spine density of striatal medium spiny neurons via SNK‐SPAR pathway in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22249
Abstract: Parkinson's disease (PD) is a well‐known neurodegenerative disorder associated with a high risk in middle‐aged and elderly individuals, severely impacting the patient's quality of life. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) is frequently used to establish PD in animals.… read more here.
Keywords: dendritic spine; mptp; density striatal; spine density ... See more keywords
Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01715-1
Abstract: Besides the effects on the striatum, the impairment of visceral organs including liver functions has been reported in Parkinson’s disease (PD) patients. However, it is yet unclear if liver functions are affected in the early… read more here.
Keywords: mptp; liver functions; non motor; exposure mptp ... See more keywords
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05693-5
Abstract: BackgroundGastrointestinal (GI) motility dysfunction is the most common non-motor symptom of Parkinson’s disease (PD). Studies have indicated that GI motility functions are impaired before the onset of PD.AimsTo investigate the underlying mechanism of PD-induced GI… read more here.
Keywords: mptp; motility; parkinson disease; colon ... See more keywords
Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal-Intestinal Inflammation Activited and Intestinal Microbiota-Metabolic Disorders Induced in MPTP Mouse Model of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03293-2
Abstract: Gut microbial dysbiosis and alteration of gut microbiota composition in Parkinson's disease (PD) have been increasingly reported, no recognized therapies are available to halt or slow progression of PD and more evidence is still needed… read more here.
Keywords: mptp; microbiota; disease; casein ... See more keywords
Programmed Death-1 Deficiency Aggravates Motor Dysfunction in MPTP Model of Parkinson's Disease by Inducing Microglial Activation and Neuroinflammation in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02758-x
Abstract: Abundant reactive gliosis and neuroinflammation are typical pathogenetic hallmarks of brains in Parkinson's disease (PD) patients, but regulation mechanisms are poorly understood. We are interested in role of programmed death-1 (PD-1) in glial reaction, neuroinflammation… read more here.
Keywords: mptp; motor dysfunction; model; neuroinflammation ... See more keywords
Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9841-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a well-known neuropeptide with strong neurotrophic and neuroprotective effects. PACAP exerts its protective actions via three G protein-coupled receptors: the specific Pac1 receptor (Pac1R) and the Vpac1/Vpac2 receptors, the… read more here.
Keywords: mptp; pacap; disease; expression ... See more keywords
Motor Neurons Pathology After Chronic Exposure to MPTP in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00121-y
Abstract: The neurotoxin 1-methyl,4-phenyl-1,2,3,6-tetrahydropiridine (MPTP) is widely used to produce experimental parkinsonism in rodents and primates. Among different administration protocols, continuous or chronic exposure to small amounts of MPTP is reported to better mimic cell pathology… read more here.
Keywords: motor neurons; mptp; spinal cord; pathology ... See more keywords