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   Articles with "mptp induced" as a keyword



FDA-Approved Secukinumab Alleviates Glial Activation and Immune Cell Infiltration in MPTP-Induced Mouse Model of Parkinson’s Disease

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recommendations! Published in 2025 at "Inflammation"

DOI: 10.1007/s10753-025-02267-8

Abstract: Interleukin-17A (IL-17A) has been implicated in the progression of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). However, the effect of the FDA-approved Secukinumab (SEC), an IL-17A inhibitor, on PD remains unclear.… read more here.

Keywords: disease; sec; activation; model ... See more keywords

Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling

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recommendations! Published in 2025 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-025-01597-8

Abstract: Xifeng Jiannao Pill (XFJNP), a traditional Chinese medicine formulation, has been shown to alleviate clinical symptoms in patients with Parkinson’s disease (PD). However, the underlying mechanisms remain unclear. Therefore, this study employs network pharmacology and… read more here.

Keywords: xfjnp; pharmacology; mapk signaling; inflammation ... See more keywords

Silymarin Protects Against Impaired Autophagy Associated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinsonism

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recommendations! Published in 2019 at "Journal of Molecular Neuroscience"

DOI: 10.1007/s12031-019-01431-8

Abstract: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exacerbates mitochondrial impairment and α-synuclein expression leading to Parkinsonism. Impaired mitochondria and over-expressed α-synuclein are degraded and eliminated via macroautophagy and chaperone-mediated autophagy. Owing to multiple properties, silymarin protects from oxidative stress–mediated cellular… read more here.

Keywords: mptp induced; methyl phenyl; parkinsonism; phenyl tetrahydropyridine ... See more keywords

Inhibition of Cyclooxygenase-2 (COX-2) Initiates Autophagy and Potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson’s Disease

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recommendations! Published in 2018 at "Molecular Neurobiology"

DOI: 10.1007/s12035-018-0950-y

Abstract: Cyclooxygenase-2 or COX-2 has been known to be crucial for Parkinson’s disease (PD) pathogenesis; however, its exact role is still not known. We first time report that inhibition of COX-2 promotes 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP)-induced… read more here.

Keywords: death; cell death; mptp induced; pathology ... See more keywords

Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.03.116

Abstract: Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress-induced neuronal death has been identified as one of the major causes of nigrostriatal degeneration… read more here.

Keywords: arguta; mice; mptp induced; parkinson disease ... See more keywords

Neuroprotective effects of MHY908, a PPAR α/γ dual agonist, in a MPTP-induced Parkinson’s disease model

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recommendations! Published in 2019 at "Brain Research"

DOI: 10.1016/j.brainres.2018.09.036

Abstract: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and are considered promising therapeutic targets in several neurodegenerative diseases. A number of PPAR agonists have been shown to have neuroprotective properties in the presence of oxidative stress,… read more here.

Keywords: mptp; ppar dual; neuroprotective effects; effects mhy908 ... See more keywords

LncRNA BDNF-AS promotes autophagy and apoptosis in MPTP-induced Parkinson’s disease via ablating microRNA-125b-5p

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recommendations! Published in 2020 at "Brain Research Bulletin"

DOI: 10.1016/j.brainresbull.2020.02.003

Abstract: BACKGROUNDS Recently, extensive evidence has indicated that the biological role of long non-coding RNAs (lncRNAs) in neurodegenerative diseases is becoming increasingly evident. The lncRNA brain-derived neurotrophic factor anti-sense (BDNF-AS) has been found to be dysregulated… read more here.

Keywords: apoptosis; parkinson disease; mptp induced; bdnf ... See more keywords

Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2018.03.086

Abstract: Parkinson's disease (PD) is a chronically progressive neurodegenerative disease, with its main pathological hallmarks being a dramatic loss of dopaminergic neurons predominantly in the Substantia Nigra (SN), and the formations of intracytoplasmic Lewy bodies and… read more here.

Keywords: mptp induced; dopaminergic; expression; regulation dopaminergic ... See more keywords

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.102431

Abstract: Summary Iron deposition is one of the key factors in the etiology of Parkinson's disease (PD). Iron-free-apoferritin has the ability to store iron by combining with a ferric hydroxide-phosphate compound to form ferritin. In this… read more here.

Keywords: mptp induced; ferroptosis; iron; apoferritin ... See more keywords

DHA enriched phospholipids with different polar groups (PC and PS) had different improvements on MPTP-induced mice with Parkinson’s disease

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recommendations! Published in 2018 at "Journal of Functional Foods"

DOI: 10.1016/j.jff.2018.04.017

Abstract: Abstract Docosahexaenoic acid (DHA) enriched phospholipids such as phosphatidylcholine (PC) and phosphatidylserine (PS) are important bioactive components and widely distributed in multifarious marine products. In the present study, we investigated the effects of DHA enriched… read more here.

Keywords: dha enriched; phospholipids different; mptp induced; enriched phospholipids ... See more keywords

Lentiviral-mediated knock-down of GD3 synthase protects against MPTP-induced motor deficits and neurodegeneration

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recommendations! Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2018.10.038

Abstract: Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in… read more here.

Keywords: gd3 synthase; lentiviral mediated; motor; mptp induced ... See more keywords