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   Articles with "mr1" as a keyword



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Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.02.017

Abstract: SUMMARY The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and fungi drive the MR1 biosynthesis pathway, viruses have not previously been implicated… read more here.

Keywords: mr1; antigen; antigen presentation; cell ... See more keywords
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MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101876

Abstract: Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response… read more here.

Keywords: pteropus alecto; mr1t cells; bat; mr1 ... See more keywords
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γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

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recommendations! Published in 2020 at "Trends in Biochemical Sciences"

DOI: 10.1016/j.tibs.2020.03.012

Abstract: Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised… read more here.

Keywords: recognition mr1; mr1 adapting; tcr recognition; adapting life ... See more keywords
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MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates

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recommendations! Published in 2017 at "Mucosal immunology"

DOI: 10.1038/mi.2016.91

Abstract: Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact… read more here.

Keywords: associated invariant; mr1; mait; mucosal associated ... See more keywords
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MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-41402-y

Abstract: The MHC-Ib molecule MR1 presents microbial metabolites to MR1-restricted T cells (MR1Ts). Given the ubiquitous expression of MR1 and the high prevalence of human MR1Ts, it is important to understand the mechanisms of MR1-dependent antigen… read more here.

Keywords: presentation; mr1; antigen presentation; infection exogenously ... See more keywords
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MAIT cells promote tumor initiation, growth and metastases via tumor MR1.

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recommendations! Published in 2019 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-19-0569

Abstract: Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I-related protein 1 (MR1) for their development. The role of MAIT cells in cancer is unclear and to date, no study has… read more here.

Keywords: growth; tumor initiation; mr1; tumor ... See more keywords
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Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1107497

Abstract: Introduction The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells). Methods Through in… read more here.

Keywords: mr1; infection; hcmv; mait cell ... See more keywords
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Fine Mapping of Rice Specific MR1, a Gene Determines Palea Identity

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2022.864099

Abstract: The hull (palea and lemma) is the specific organ of grass florets. Although many genes related to the hull development have been cloned, the genetic mechanisms behind the development are still unclear, and the evolutionary… read more here.

Keywords: specific mr1; mr1; identity; mrp ... See more keywords