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   Articles with "mr1" as a keyword



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Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.02.017

Abstract: SUMMARY The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and fungi drive the MR1 biosynthesis pathway, viruses have not previously been implicated… read more here.

Keywords: mr1; antigen; antigen presentation; cell ... See more keywords

MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101876

Abstract: Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response… read more here.

Keywords: pteropus alecto; mr1t cells; bat; mr1 ... See more keywords
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γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

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recommendations! Published in 2020 at "Trends in Biochemical Sciences"

DOI: 10.1016/j.tibs.2020.03.012

Abstract: Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised… read more here.

Keywords: recognition mr1; mr1 adapting; tcr recognition; adapting life ... See more keywords

MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates

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recommendations! Published in 2017 at "Mucosal immunology"

DOI: 10.1038/mi.2016.91

Abstract: Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact… read more here.

Keywords: associated invariant; mr1; mait; mucosal associated ... See more keywords

MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-41402-y

Abstract: The MHC-Ib molecule MR1 presents microbial metabolites to MR1-restricted T cells (MR1Ts). Given the ubiquitous expression of MR1 and the high prevalence of human MR1Ts, it is important to understand the mechanisms of MR1-dependent antigen… read more here.

Keywords: presentation; mr1; antigen presentation; infection exogenously ... See more keywords

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-024-05912-4

Abstract: MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways. To investigate ligand exchange pathways for… read more here.

Keywords: antigen; monomer; cell; mr1 ... See more keywords

MAIT cells promote tumor initiation, growth and metastases via tumor MR1.

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recommendations! Published in 2019 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-19-0569

Abstract: Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I-related protein 1 (MR1) for their development. The role of MAIT cells in cancer is unclear and to date, no study has… read more here.

Keywords: growth; tumor initiation; mr1; tumor ... See more keywords

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1107497

Abstract: Introduction The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells). Methods Through in… read more here.

Keywords: mr1; infection; hcmv; mait cell ... See more keywords

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1547664

Abstract: Introduction The MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted… read more here.

Keywords: cell receptor; mr1 restricted; cell; mr1 ... See more keywords

Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

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recommendations! Published in 2024 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2024.1419528

Abstract: Background Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-restricted TCRs specific… read more here.

Keywords: cancer; mr1 restricted; specificity; biology ... See more keywords

Fine Mapping of Rice Specific MR1, a Gene Determines Palea Identity

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2022.864099

Abstract: The hull (palea and lemma) is the specific organ of grass florets. Although many genes related to the hull development have been cloned, the genetic mechanisms behind the development are still unclear, and the evolutionary… read more here.

Keywords: specific mr1; mr1; identity; mrp ... See more keywords