MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto
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DOI: 10.1016/j.isci.2020.101876
Abstract: Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response… read more here.
Keywords: pteropus alecto; mr1t cells; bat; mr1 ... See more keywords
Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor
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DOI: 10.3389/fimmu.2025.1547664
Abstract: Introduction The MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted… read more here.
Keywords: cell receptor; mr1 restricted; cell; mr1 ... See more keywords
Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs
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DOI: 10.3389/fonc.2024.1419528
Abstract: Background Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-restricted TCRs specific… read more here.
Keywords: cancer; mr1 restricted; specificity; biology ... See more keywords