Pre-Transplant MRD Negativity Predicts Favorable Outcomes of CAR-T Therapy Followed By Haploidentical HSCT for Relapsed/Refractory Acute Lymphoblastic Leukemia: A Multi-Center Retrospective Study
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DOI: 10.1182/blood-2019-128399
Abstract: Patients with relapsed/refractory acute lymphoblastic leukemia (R/R ALL) usually have a very poor prognosis and an expected survival of less than 6 months.The complete remission (CR) rates in the setting of the first salvage chemotherapy… read more here.
Keywords: positive relapse; mrd positive; group; mrd negative ... See more keywords
Conversion from MRD Positive to Negative Status in AML Patients in CR1 after Treatment with an Allogeneic Leukemia-Derived Dendritic Cell Vaccine
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DOI: 10.1182/blood-2020-139266
Abstract: Background. Persistence of measurable residual disease (MRD) in patients with acute myeloid leukemia (AML) remains a poor prognostic factor and unmet medical need. The allogeneic leukemia-derived dendritic cell vaccine, DCP-001, has shown in a phase… read more here.
Keywords: response; consultancy honoraria; vaccine; vaccination ... See more keywords
Low-Dose Decitabine Plus Venetoclax Maintenance Therapy Can Decrease the Relapse after Allogeneic Stem Cell Transplantation for MRD Positive High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
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DOI: 10.1182/blood-2020-140359
Abstract: Background: Acute myeloid leukemia (AML) and myelodysplasia (MDS) are usually associated with poor outcomes, especially in high-risk AML/MDS. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curable option for patients suffering from high-risk AML/MDS.… read more here.
Keywords: aml mds; high risk; positive high; transplantation ... See more keywords
Minimal residual disease status improved the response evaluation in patients with Waldenström’s macroglobulinemia
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DOI: 10.3389/fimmu.2023.1171539
Abstract: Introduction Minimal residual disease (MRD) has been recognized as an important prognostic factor of survival in patients with hematological malignancies. However, the prognostic value of MRD in Waldenström macroglobulinemia (WM) remains unexplored. Methods We analyzed… read more here.
Keywords: residual disease; waldenstr macroglobulinemia; mrd positive; minimal residual ... See more keywords