An in-silico analysis to identify structural, functional and regulatory role of SNPs in hMRE11
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2028678
Abstract: ABSTRACT Meiotic recombination 11 (MRE11) is a component of the tri-molecular MRE11-RAD50-NBS1 (MRN) complex, which functions as an exonuclease and endonuclease which is involved in identifying, signalling, protecting and repairing double-strand breaks in DNA (DSBs).… read more here.
Keywords: role; analysis identify; mre11; snps ... See more keywords
Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky086
Abstract: Abstract Sae2 cooperates with the Mre11–Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute… read more here.
Keywords: dna damage; sae2; end tethering; resistance ... See more keywords
GRB2 enforces homology-directed repair initiation by MRE11
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DOI: 10.1126/sciadv.abe9254
Abstract: GRB2 controls radiation-induced DNA damage repair—a predictive biomarker for PARPi and radiation therapy outcome. DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here,… read more here.
Keywords: directed repair; hdr; homology directed; grb2 ... See more keywords
High expression of MRE11 correlates with poor prognosis in gastric carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Pathology"
DOI: 10.1186/s13000-019-0844-y
Abstract: BackgroundMRE11, a protein known to play a vital role in DNA double-strand break repair, is associated with the prognosis of a variety of tumours, but there are few studies regarding the role of MRE11 in… read more here.
Keywords: gastric carcinoma; expression; poor prognosis; mre11 ... See more keywords
CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050841
Abstract: Oral cancer is one of the highest-incidence malignancies worldwide, with the occurrence of oral squamous cell carcinoma (OSCC) being the most frequently diagnosed form. A barrier for oral cancer management may arise from tumor cells… read more here.
Keywords: cell; cd44; mre11; oral squamous ... See more keywords