Mre11-Rad50: the DNA end game.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220754
Abstract: The Mre11-Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of life. It is an intricate DNA associated molecular machine that cuts, among… read more here.
Keywords: dna; mre11 rad50; dna end;
MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
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DOI: 10.1186/s12943-019-1100-5
Abstract: Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays… read more here.
Keywords: dna damage; nbs1 complex; cancer; rad50 nbs1 ... See more keywords
MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20040816
Abstract: The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has sparked interest in its role in colorectal cancer (CRC). To date, there is… read more here.
Keywords: mrn; colorectal cancer; mrn complex; cancer ... See more keywords