MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
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DOI: 10.1038/s41467-024-49740-w
Abstract: Oncogene-induced senescence (OIS) arrests cell proliferation in response to replication stress (RS) induced by oncogenes. OIS depends on the DNA damage response (DDR), but also on the cGAS-STING pathway, which detects cytosolic DNA and induces… read more here.
Keywords: senescence; replication stress; mre11 trex1; oncogene ... See more keywords