Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01709
Abstract: Mas-related G protein-coupled receptor X1 (MRGPRX1) is a human sensory neuron-specific receptor and potential target for the treatment of pain. Positive allosteric modulators (PAMs) of MRGPRX1 have the potential to preferentially activate the receptors at… read more here.
Keywords: mrgprx1; receptor; thieno pyrimidine; mas related ... See more keywords
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1
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DOI: 10.3390/ijms232214321
Abstract: Chloroquine (CQ) is an antimalaria drug that has been widely used for decades. However, CQ-induced pruritus remains one of the major obstacles in CQ treatment for uncomplicated malaria. Recent studies have revealed that MrgprX1 plays… read more here.
Keywords: induced pruritus; induced itch; mrgprx1; berbamine ... See more keywords