Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7445
Abstract: Mas‐related G protein‐coupled receptor X2 (MRGPRX2) mediates mast cells (MCs) activation, which is a key target for the treatment of allergic diseases. However, there are few drugs targeting MRGPRX2. Leukocyte mono‐immunoglobulin‐like receptor 3 (CD300f) is… read more here.
Keywords: negatively regulated; pseudo allergic; regulated mrgprx2; mrgprx2 ... See more keywords
Identification of short peptide sequences that activate human mast cells via Mas-related G-protein coupled receptor member X2.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.09.011
Abstract: Peptide based therapeutics are desirable owing to their high biological specificity. However, a number of these fail in clinical testing due to an adverse inflammatory response. Mast cells play a key role in directing the… read more here.
Keywords: peptide; mrgprx2; mast cells; mast ... See more keywords
Dextromethorphan - A widely-used cough suppressant - Induces local anaphylaxis via MRGPRX2 on mast cells.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109248
Abstract: Dextromethorphan (DM) is a cough suppressant available in many prescribed and over-the-counter medications. Adverse reactions induced by DM have been regularly reported, including allergic skin reactions in some cases. However, the underlying mechanisms of local… read more here.
Keywords: mrgprx2; mast cells; mast; via mrgprx2 ... See more keywords
Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2
Sign Up to like & getrecommendations! Published in 2023 at "Disease Markers"
DOI: 10.1155/2023/9049256
Abstract: Background Atopic dermatitis is a common dermatological disease, and mast cell degranulation is believed to be related with the progression of atopic dermatitis. Mas-related G protein-coupled receptor-X2 (MRGPRX2), and calcium release-activated calcium channel protein 1-2… read more here.
Keywords: dermatitis; mrgprx2; atopic dermatitis; celastrol ... See more keywords
Roles of a Mast Cell–Specific Receptor MRGPRX2 in Host Defense and Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dental Research"
DOI: 10.1177/0022034520919107
Abstract: Mast cells are multifunctional immune cells that are found most abundantly at host-environment interfaces, such as the skin, respiratory tract, and oral/gastrointestinal mucosa. Not surprisingly, mast cells act as sentinel cells that sense microbial attacks… read more here.
Keywords: mast cells; mast; host defense; mrgprx2 ... See more keywords
Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1026304
Abstract: Background Occupancy of MRGPRX2 heralds a new era in our understandings of immediate drug hypersensitivity reactions (IDHRs), but a constitutive expression of this receptor by basophils is debated. Objective To explore the expression and functionality… read more here.
Keywords: mrgprx2; expression; moxifloxacin; stimulation anti ... See more keywords
Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1033794
Abstract: Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs) contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) approved drugs such as the neuromuscular blocking agent, rocuronium. In addition, activation of MRGPRX2… read more here.
Keywords: cell; mrgprx2; pamp; receptor ... See more keywords
Spatiotemporal Patterns of Substance P-Bound MRGPRX2 Reveal a Novel Connection Between Macropinosome Resolution and Secretory Granule Regeneration in Mast Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.892239
Abstract: MRGPRX2, the human member of the MAS-related G protein coupled receptors (Mrgprs), serves as the cellular target of human mast cells (MCs) for innate ligands, including neuropeptides and antimicrobial peptides. In addition, MRGPRX2 also functions… read more here.
Keywords: spatiotemporal patterns; mrgprx2; macropinosome resolution; resolution ... See more keywords
The Number of MRGPRX2-Expressing Cells Is Increased in Skin Lesions of Patients With Indolent Systemic Mastocytosis, But Is Not Linked to Symptom Severity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.930945
Abstract: Background Recently, the expression of the mast cell (MC) receptor Mas-related G protein–coupled receptor X2 (MRGPRX2) has been detected in lesional skin of adult patients with cutaneous mastocytosis. As of yet, little is known about… read more here.
Keywords: mastocytosis; symptom severity; mrgprx2; lesional skin ... See more keywords
MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1154108
Abstract: MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate hypersensitivity and has been… read more here.
Keywords: mitf activity; mrgprx2 signaling; mrgprx2; mitf pathway ... See more keywords