Noninvasive, Quantitative Assessment of Liver Fat by MRI‐PDFF as an Endpoint in NASH Trials
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DOI: 10.1002/hep.29797
Abstract: Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver… read more here.
Keywords: nash trials; noninvasive quantitative; liver; mri pdff ... See more keywords
MRI Assessment of Treatment Response in HIV‐associated NAFLD: A Randomized Trial of a Stearoyl‐Coenzyme‐A‐Desaturase‐1 Inhibitor (ARRIVE Trial)
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DOI: 10.1002/hep.30674
Abstract: Aramchol, an oral stearoyl‐coenzyme‐A‐desaturase‐1 inhibitor, has been shown to reduce hepatic fat content in patients with primary nonalcoholic fatty liver disease (NAFLD); however, its effect in patients with human immunodeficiency virus (HIV)–associated NAFLD is unknown.… read more here.
Keywords: trial; treatment; mri; associated nafld ... See more keywords
A Standardized Approach for MRI‐PDFF is Necessary in the Assessment of Diagnostic Performances of the Ultrasound‐Based Hepatic Fat Quantification Tools
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.16102
Abstract: The recently developed ultrasound‐based hepatic fat quantification tools have the potential to be implemented in daily practice with wide acceptance due to inherited advantages of ultrasound technology. Researchers intensively focused on this topic and the… read more here.
Keywords: fat quantification; pdff; based hepatic; hepatic fat ... See more keywords
Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.09.024
Abstract: BACKGROUND & AIMS Non-invasive tools for monitoring treatment response and disease progression in non-alcoholic steatohepatitis (NASH) are needed. Our objective was to evaluate the utility of magnetic resonance (MR)-based hepatic imaging measures for the assessment… read more here.
Keywords: non alcoholic; histology; alcoholic steatohepatitis; liver ... See more keywords
SAT-347-MRI-PDFF response in MGL-3196 and placebo treated patients predicts reduction in ballooning and inflammation components of NAS and NASH resolution in a 36-week serial liver biopsy study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hepatology"
DOI: 10.1016/s0618-8278(19)31577-4
Abstract: MRI-PDFF response in MGL-3196 and placebo treated patients predicts reduction in ballooning and inflammation components of NAS and NASH resolution in a 36-week serial liver biopsy study Stephen Harrison1, Cynthia Guy2, Rebecca Taub3, Mustafa Bashir2… read more here.
Keywords: pdff response; 3196 placebo; mri pdff; mgl 3196 ... See more keywords
Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2016.10.026
Abstract: BACKGROUND & AIMS Magnetic resonance imaging (MRI) techniques and ultrasound-based transient elastography (TE) can be used in noninvasive diagnosis of fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD). We performed a prospective… read more here.
Keywords: fibrosis; steatosis patients; magnetic resonance; elastography ... See more keywords
Liver Ultrasound Attenuation
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DOI: 10.1097/ruq.0000000000000605
Abstract: Objectives Nonalcoholic fatty liver disease (NAFLD) is the most widespread chronic liver disease type in the Western countries. Ultrasound (US) is used for NAFLD and hepatic steatosis (HS) grading. The most popular US method for… read more here.
Keywords: lisa hri; liver ultrasound; ultrasound attenuation; hri ... See more keywords
Two-dimensional Convolutional Neural Network Using Quantitative US for Noninvasive Assessment of Hepatic Steatosis in NAFLD.
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DOI: 10.1148/radiol.221510
Abstract: Background Quantitative US (QUS) using radiofrequency data analysis has been recently introduced for noninvasive evaluation of hepatic steatosis. Deep learning algorithms may improve the diagnostic performance of QUS for hepatic steatosis. Purpose To evaluate a… read more here.
Keywords: steatosis; two dimensional; hepatic steatosis; mri pdff ... See more keywords
Steatosis grading consistency between controlled attenuation parameter and MRI-PDFF in monitoring metabolic associated fatty liver disease
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/20406223211033119
Abstract: Background: The consistency in steatosis grading between magnetic resonance imaging-based proton density fat fraction (MRI-PDFF) and controlled attenuation parameter (CAP) before and after treatment remains unclear. This study aimed to compare the diagnostic accuracy of… read more here.
Keywords: steatosis; steatosis grading; cap; mri pdff ... See more keywords
A pilot study of ex-vivo MRI-PDFF of donor livers for assessment of steatosis and predicting early graft dysfunction
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DOI: 10.1371/journal.pone.0232006
Abstract: Background The utility of ex vivo Magnetic resonance imaging proton density fat fraction (MRI-PDFF) in donor liver fat quantification is unknown. Purpose To evaluate the diagnostic accuracy and utility in predicting early allograft dysfunction (EAD)… read more here.
Keywords: steatosis; donor livers; mri pdff; histology ... See more keywords
Noninvasive assessment of hepatic steatosis using a pathologic reference standard: comparison of CT, MRI, and US-based techniques
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DOI: 10.14366/usg.21150
Abstract: Purpose The present study compared the performance of computed tomography (CT), magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF), controlled attenuation parameter (CAP), grayscale ultrasonography (US), and attenuation imaging (ATI) for the diagnosis of hepatic… read more here.
Keywords: mri pdff; performance; hepatic steatosis; mri ... See more keywords