The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ
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DOI: 10.1016/j.bbr.2018.07.013
Abstract: HighlightsRepeated peripheral LPS administration increases expression of central A&bgr;.Administration of MRK‐016 post‐training rescues memory consolidation following LPS administration.MRK‐016‐treated animals showed BDNF mRNA expression comparable to control animals.Repeated injections of LPS and increased A&bgr; expression are… read more here.
Keywords: lps treated; mrk 016; expression; hippocampal bgr ... See more keywords