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   Articles with "mrl lpr" as a keyword



miR-7213-5p-mediated suppression of CCL19 in fibroblast cells may attenuate lupus nephritis

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recommendations! Published in 2025 at "Clinical and Experimental Medicine"

DOI: 10.1007/s10238-025-01960-0

Abstract: Lupus nephritis (LN) is an immune-complex nephritis and one of the most severe organ manifestations of systemic lupus erythematosus. To elucidate the mechanisms underlying LN, we firstly performed comprehensive RNA sequencing and microRNA (miRNA) sequencing… read more here.

Keywords: ccl19; nephritis; mrl lpr; mir 7213 ... See more keywords

Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M.

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recommendations! Published in 2025 at "Inflammation"

DOI: 10.1007/s10753-025-02347-9

Abstract: There is a recognized longitudinal association between serum nitrogen oxides levels and disease activity in lupus nephritis. Recently, increased exposure to high levels of nitrite has raised significant concerns, though its impact on lupus pathogenesis… read more here.

Keywords: integrin alpha; mrl lpr; lupus mrl; lpr mice ... See more keywords

Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice.

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recommendations! Published in 2020 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2020.107027

Abstract: FoxO3a plays key roles in inflammation and autoimmunity, and the PI3K-Akt-FoxO3a pathway has been proposed to modulate diverse biological processes. The aim of the present study, using lupus murine models, was to investigate whether FoxO3a… read more here.

Keywords: mrl lpr; lpr mice; upregulation foxo3a; pi3k akt ... See more keywords

Administration of a microRNA-21 inhibitor improves the lupus-like phenotype in MRL/lpr mice by repressing Tfh cell-mediated autoimmune responses.

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recommendations! Published in 2022 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2022.108578

Abstract: BACKGROUND Inhibiting Tfh cell overexpansion prevents autoimmune responses and disease flares in systemic lupus erythematosus (SLE). miR-21 is highly expressed in SLE CD4+ T cells, but whether inhibiting miR-21 can reduce Tfh cell expansion and… read more here.

Keywords: tfh cell; lpr mice; mrl lpr; tfh ... See more keywords
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A novel BAFF antagonist, BAFF-Trap, effectively alleviates the disease progression of systemic lupus erythematosus in MRL/lpr mice.

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recommendations! Published in 2020 at "Molecular immunology"

DOI: 10.1016/j.molimm.2020.11.010

Abstract: Abnormal B cells, which produce antibodies against self-antigens, play a key role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). B-cell activating factor (BAFF) is closely associated… read more here.

Keywords: baff trap; systemic lupus; lupus erythematosus; mrl lpr ... See more keywords

130. Nicotinamide alleviates preeclampsia-like features and lupus nephritis in pregnant MRL/lpr mice treated with LPS

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recommendations! Published in 2018 at "Pregnancy Hypertension"

DOI: 10.1016/j.preghy.2018.08.241

Abstract: Introduction Systemic Lupus Erythematosus (SLE) increases the risk of unfavorable pregnancy outcomes including preterm birth and preeclampsia (PE). Flare-up of SLE during pregnancy or after birth is also problematic. TLR4 signaling is known to exacerbate… read more here.

Keywords: mrl lpr; mrl; pregnancy; lpr mice ... See more keywords

Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-38809-y

Abstract: Global DNA hypomethylation in CD4+ cells in systemic lupus erythematosus (SLE) was suggested to play a key role in the pathogenesis. To identify new methylation-sensitive genes, we integrated genome-wide DNA methylation and mRNA profiling data… read more here.

Keywords: cd4 cells; mcgcg; mrl lpr; expression ... See more keywords

Mesenchymal Stem Cells-derived Exosomes Ameliorate Lupus by Inducing M2 Macrophage Polarization and Regulatory T Cell Expansion in MRL/lpr Mice

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recommendations! Published in 2022 at "Immunological Investigations"

DOI: 10.1080/08820139.2022.2055478

Abstract: ABSTRACT Previous studies have implicated that the transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) effectively alleviates systemic lupus erythematosus (SLE) primarily due to immunomodulatory effects. However, little is known about the role of… read more here.

Keywords: lpr mice; derived exosomes; mesenchymal stem; msc exosomes ... See more keywords

Recombinant Protein UBC13 Improves Tissue Injury of MRL/Lpr Mice by Alleviating Th1/Th2 Immune Imbalance

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recommendations! Published in 2025 at "Immunological Investigations"

DOI: 10.1080/08820139.2025.2509086

Abstract: ABSTRACT Objectives This study aimed to investigate the role of T-cell imbalance in the pathogenesis of systemic lupus erythematosus (SLE), the role of Ubiquitin-binding enzyme 2N (UBC13) in the treatment of SLE. Methods Mice in… read more here.

Keywords: mrl lpr; cell; th2; lpr mice ... See more keywords

Establishment of a lupus-prone mouse model of pulmonary arterial hypertension with intermittent hypoxia: functional, biochemical and histological verifications.

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recommendations! Published in 2025 at "Clinical and experimental hypertension"

DOI: 10.1080/10641963.2025.2500383

Abstract: ABSTRACT Pulmonary arterial hypertension (PAH) is one of the most severe complications of systemic lupus erythematosus (SLE) with high mortality and limited treatment options, primarily due to its unclear pathogenesis. This study aims to investigate… read more here.

Keywords: hypertension; lpr mice; pulmonary arterial; mrl lpr ... See more keywords

Dexamethasone reduces autoantibody levels in MRL/lpr mice by inhibiting Tfh cell responses

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recommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.16785

Abstract: Previous studies have shown that dexamethasone (Dex) reduces the levels of anti‐nuclear (ANA) and anti‐dsDNA antibodies in MRL/lpr mice (a mouse model of SLE). However, the effect of Dex on T follicular helper (Tfh) cells… read more here.

Keywords: lpr mice; dex; tfh; mrl lpr ... See more keywords