A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0760-1
Abstract: Chromosomal breaks can be healed by several repair processes, including one called non-homologous end-joining (NHEJ) where the two broken ends are ligated together with a loss of 0–5 bp of DNA. The protein requirements for NHEJ… read more here.
Keywords: end joining; schizosaccharomyces pombe; homologous end; mrn ... See more keywords
Magnetic Resonance Navigation for Targeted Embolization in a Two-Level Bifurcation Phantom
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-019-02317-x
Abstract: This work combines a particle injection system with our proposed magnetic resonance navigation (MRN) sequence with the intention of validating MRN in a two-bifurcation phantom for endovascular treatment of hepatocellular carcinoma (HCC). A theoretical physical… read more here.
Keywords: resonance navigation; bifurcation phantom; magnetic resonance; mrn ... See more keywords
Structural basis for DNA break sensing by human MRE11-RAD50-NBS1 and its regulation by telomeric factor TRF2
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64082-x
Abstract: The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generic and telomeric DNA ends and can separate… read more here.
Keywords: mre11 rad50; mrn; factor trf2; dna ... See more keywords
Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.
Sign Up to like & getrecommendations! Published in 2024 at "Human molecular genetics"
DOI: 10.1093/hmg/ddae101
Abstract: The MRE11/RAD50/NBS1 (MRN) complex plays critical roles in cellular responses to DNA double-strand breaks. MRN is involved in end binding and processing, and it also induces cell cycle checkpoints by activating the ataxia-telangiectasia mutated (ATM)… read more here.
Keywords: disease; telangiectasia like; distinct ataxia; ataxia telangiectasia ... See more keywords
PARP1-TRIM44-MRN loop dictates the response to PARP inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae756
Abstract: Abstract PARP inhibitors (PARPi) show selective efficacy in tumors with homologous recombination repair (HRR)-defects but the activation mechanism of HRR pathway in PARPi-treated cells remains enigmatic. To unveil it, we searched for the mediator bridging… read more here.
Keywords: parp inhibitors; mrn complex; mrn; parp1 trim44 ... See more keywords
Magnetic Resonance Neurography of the Lumbosacral Plexus in Failed Back Surgery Syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Spine"
DOI: 10.1097/brs.0000000000002460
Abstract: STUDY DESIGN Retrospective clinical case series. OBJECTIVE To study the role of magnetic resonance neurography (MRN) of the lumbosacral plexus in management of patients with failed back surgery syndrome (FBSS). SUMMARY OF BACKGROUND DATA FBSS… read more here.
Keywords: mrn; resonance neurography; magnetic resonance; lumbosacral plexus ... See more keywords
Somatotopic Fascicular Lesions of the Brachial Plexus Demonstrated by High-Resolution Magnetic Resonance Neurography
Sign Up to like & getrecommendations! Published in 2017 at "Investigative Radiology"
DOI: 10.1097/rli.0000000000000401
Abstract: Objectives The aim of this study was to evaluate whether high-resolution brachial plexus (BP) magnetic resonance neurography (MRN) is capable of (1) distinguishing patients with compressive neuropathy or noncompressive plexopathy from age- and sex-matched controls,… read more here.
Keywords: resolution; high resolution; magnetic resonance; brachial plexus ... See more keywords
Peripheral nerve involvement in hereditary spastic paraplegia characterized by quantitative magnetic resonance neurography.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of neurology"
DOI: 10.1111/ene.15841
Abstract: BACKGROUND AND OBJECTIVES Hereditary spastic paraplegias (HSP) are heterogenous genetic disorders. While peripheral nerve involvement is frequent in spastic paraplegia (SPG) 7, the evidence of peripheral nerve involvement in SPG4 is more controversial. Here, we… read more here.
Keywords: mrn; peripheral nerve; spg4 spg7; nerve involvement ... See more keywords
MRN Complex and Cancer Risk: Old Bottles, New Wine
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-1509
Abstract: The MRN complex, composed of MRE11A, RAD50, and NBN, mediates vital molecular functions to maintain genomic stability and hence protect against related disorders. Germline mutations in the MRN genes predispose to three different syndromes: ataxia-telangiectasia-like… read more here.
Keywords: mrn complex; mrn; mrn genes; cancer ... See more keywords
The MRN complex of wheat.
Sign Up to like & getrecommendations! Published in 2018 at "Czech Journal of Genetics and Plant Breeding"
DOI: 10.17221/3251-cjgpb
Abstract: The MRN complex is formed by the interaction of the products of the Mre11, Rad50 and Nbs1 genes. This complex plays a central role on repair of double-strand breaks (DSBs) and acts in a great… read more here.
Keywords: complex wheat; mrn complex; interaction proteins; expression ... See more keywords
DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215278
Abstract: Simple Summary The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating DNA double-strand break repair and activating several downstream proteins. These proteins have been studied for their individual roles in inherited cancers and are included on… read more here.
Keywords: mrn; mrn complex; dna repair; cancer ... See more keywords