MRN Complex and Cancer Risk: Old Bottles, New Wine
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-1509
Abstract: The MRN complex, composed of MRE11A, RAD50, and NBN, mediates vital molecular functions to maintain genomic stability and hence protect against related disorders. Germline mutations in the MRN genes predispose to three different syndromes: ataxia-telangiectasia-like… read more here.
Keywords: mrn complex; mrn; mrn genes; cancer ... See more keywords
The MRN complex of wheat.
Sign Up to like & getrecommendations! Published in 2018 at "Czech Journal of Genetics and Plant Breeding"
DOI: 10.17221/3251-cjgpb
Abstract: The MRN complex is formed by the interaction of the products of the Mre11, Rad50 and Nbs1 genes. This complex plays a central role on repair of double-strand breaks (DSBs) and acts in a great… read more here.
Keywords: complex wheat; mrn complex; interaction proteins; expression ... See more keywords
DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215278
Abstract: Simple Summary The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating DNA double-strand break repair and activating several downstream proteins. These proteins have been studied for their individual roles in inherited cancers and are included on… read more here.
Keywords: mrn; mrn complex; dna repair; cancer ... See more keywords
MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20040816
Abstract: The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has sparked interest in its role in colorectal cancer (CRC). To date, there is… read more here.
Keywords: mrn; colorectal cancer; mrn complex; cancer ... See more keywords