First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.38039
Abstract: Key Points Question Are messenger RNA (mRNA)–based COVID-19 vaccines teratogenic ? Findings In this nationwide cohort study of 527 564 live-born infants, 130 338 (24.7%) were exposed to an mRNA-based COVID-19 vaccine during the first trimester of… read more here.
Keywords: mrna based; major congenital; based covid; risk ... See more keywords
Synthetic mRNA‐Based Systems in Mammalian Cells
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DOI: 10.1002/adbi.201900247
Abstract: Living organisms are programmed to perform multiple functions by sensing intra‐ and extra‐cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing genetic circuits. Synthetic mRNA‐based genetic… read more here.
Keywords: based systems; synthetic mrna; mrna based; systems mammalian ... See more keywords
Recent advances in mRNA‐based vaccine for cancer therapy; bench to bedside
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3954
Abstract: The messenger RNA (mRNA) vaccines have progressed from a theoretical concept to a clinical reality over the last few decades. Compared to conventional vaccination methods, these vaccines have a number of benefits, such as substantial… read more here.
Keywords: cancer; mrna based; based vaccine; advances mrna ... See more keywords
A Vector-Based Vaccine Dose After 3 Doses of mRNA-Based COVID-19 Vaccination Does Not Substantially Improve Humoral SARS-CoV-2 Immunity in Renal Transplant Recipients
Sign Up to like & getrecommendations! Published in 2022 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2022.01.1068
Abstract: To the Editor: COVID-19–related mortality in kidney transplant recipients (KTX) is significantly higher when compared with nontransplant patients. Vaccination against SARS-CoV-2 is the most efficient measure to protect this vulnerable population. Nevertheless, after the application… read more here.
Keywords: transplant recipients; based vaccine; vaccination; mrna based ... See more keywords
Interstitial lung disease after receiving the mRNA-based COVID-19 vaccine tozinameran
Sign Up to like & getrecommendations! Published in 2022 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2022.101618
Abstract: Tozinameran, a messenger ribonucleic acid (mRNA)-based coronavirus disease 19 (COVID-19) vaccine, has a favorable safety profile and is highly efficacious in preventing COVID-19. Adverse reactions such as pain at the vaccination site, fever, malaise, headache,… read more here.
Keywords: covid vaccine; based covid; interstitial lung; disease ... See more keywords
mRNA-Based Cancer Vaccines: Advancements and Prospects.
Sign Up to like & getrecommendations! Published in 2024 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c03296
Abstract: The success of mRNA COVID-19 vaccines has reinvigorated research and interest in mRNA-based cancer vaccines. Despite promising results in clinical trials, therapeutic mRNA-based cancer vaccines have not yet been approved for human use. These vaccines… read more here.
Keywords: cancer; mrna based; based cancer; advancements prospects ... See more keywords
The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors
Sign Up to like & getrecommendations! Published in 2024 at "Cell Discovery"
DOI: 10.1038/s41421-024-00743-3
Abstract: We investigated a novel cancer immunotherapy strategy that effectively suppresses tumor growth in multiple solid tumor models and significantly extends the lifespan of tumor-bearing mice by introducing pathogen antigens into tumors via mRNA-lipid nanoparticles. The… read more here.
Keywords: mrna based; immune responses; immunity; memory immunity ... See more keywords
Long-term risk of autoimmune diseases after mRNA-based SARS-CoV2 vaccination in a Korean, nationwide, population-based cohort study
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50656-8
Abstract: The long-term association between mRNA-based coronavirus disease 2019 (COVID-19) vaccination and the development of autoimmune connective tissue diseases (AI-CTDs) remains unclear. In this nationwide, population-based cohort study involving 9,258,803 individuals, we aim to determine whether… read more here.
Keywords: based cohort; mrna based; risk; vaccination ... See more keywords
Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Nature Nanotechnology"
DOI: 10.1038/s41565-022-01071-x
Abstract: After over a billion of vaccinations with messenger RNA-lipid nanoparticle (mRNA-LNP) based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can be considered as very rare adverse events. Although current recommendations include avoiding a second… read more here.
Keywords: cov vaccines; mrna based; based sars; reactions mrna ... See more keywords
Development and immunological evaluation of an mRNA-based vaccine targeting Naegleria fowleri for the treatment of primary amoebic meningoencephalitis
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-023-51127-8
Abstract: More than 95% of patients fall victim to primary amoebic meningoencephalitis (PAM), a fatal disease attacking the central nervous system. Naegleria fowleri , a brain-eating microorganism, is PAM's most well-known pathogenic ameboflagellate. Despite the use… read more here.
Keywords: amoebic meningoencephalitis; mrna based; based vaccine; naegleria fowleri ... See more keywords
Medical and molecular biophysical techniques as substantial tools in the era of mRNA-based vaccine technology.
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials science"
DOI: 10.1039/d4bm00561a
Abstract: The COVID-19 pandemic prompted the advancement of vaccine technology using mRNA delivery into the host cells. Consequently, mRNA-based vaccines have emerged as a practical approach against SARS-CoV-2 owing to their inherent properties, such as cost-effectiveness,… read more here.
Keywords: mrna based; biophysical techniques; medical molecular; molecular biophysical ... See more keywords