Synthetic mRNA‐Based Systems in Mammalian Cells
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DOI: 10.1002/adbi.201900247
Abstract: Living organisms are programmed to perform multiple functions by sensing intra‐ and extra‐cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing genetic circuits. Synthetic mRNA‐based genetic… read more here.
Keywords: based systems; synthetic mrna; mrna based; systems mammalian ... See more keywords
A Vector-Based Vaccine Dose After 3 Doses of mRNA-Based COVID-19 Vaccination Does Not Substantially Improve Humoral SARS-CoV-2 Immunity in Renal Transplant Recipients
Sign Up to like & getrecommendations! Published in 2022 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2022.01.1068
Abstract: To the Editor: COVID-19–related mortality in kidney transplant recipients (KTX) is significantly higher when compared with nontransplant patients. Vaccination against SARS-CoV-2 is the most efficient measure to protect this vulnerable population. Nevertheless, after the application… read more here.
Keywords: transplant recipients; based vaccine; vaccination; mrna based ... See more keywords
Interstitial lung disease after receiving the mRNA-based COVID-19 vaccine tozinameran
Sign Up to like & getrecommendations! Published in 2022 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2022.101618
Abstract: Tozinameran, a messenger ribonucleic acid (mRNA)-based coronavirus disease 19 (COVID-19) vaccine, has a favorable safety profile and is highly efficacious in preventing COVID-19. Adverse reactions such as pain at the vaccination site, fever, malaise, headache,… read more here.
Keywords: covid vaccine; based covid; interstitial lung; disease ... See more keywords
Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Nature Nanotechnology"
DOI: 10.1038/s41565-022-01071-x
Abstract: After over a billion of vaccinations with messenger RNA-lipid nanoparticle (mRNA-LNP) based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can be considered as very rare adverse events. Although current recommendations include avoiding a second… read more here.
Keywords: cov vaccines; mrna based; based sars; reactions mrna ... See more keywords
An overview of rational design of mRNA-based therapeutics and vaccines
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DOI: 10.1080/17460441.2021.1935859
Abstract: ABSTRACT Introduction Messenger RNA (mRNA)-based therapeutics and vaccines have emerged as a disruptive new drug class for various applications, including regenerative medicine, cancer treatment, and prophylactic and therapeutic vaccinations. Areas covered This review provides an… read more here.
Keywords: mrna based; based therapeutics; overview rational; therapeutics vaccines ... See more keywords
Surrogate neutralisation responses following SARS-CoV-2 vaccination in people living with HIV - comparison between inactivated and mRNA vaccine.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003237
Abstract: OBJECTIVE People living with HIV (PLHIV) co-infected with SARS-CoV-2 are at higher odds of severe diseases. Whereas the immunogenicity of mRNA vaccine and adenovirus-vectored vaccine was similar between PLHIV in stable condition and healthy adults,… read more here.
Keywords: living hiv; sars cov; mrna vaccine; mrna based ... See more keywords
Strong antibody response after a first dose of a SARS‐CoV‐2 mRNA‐based vaccine in kidney transplant recipients with a previous history of COVID‐19
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16764
Abstract: A recent study demonstrated that a single dose of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA-based vaccine is sufficient to mount a robust immunological response in immunocompetent subjects with a previous history of… read more here.
Keywords: based vaccine; mrna based; cov mrna; covid ... See more keywords
Implications of mRNA-based SARS-CoV-2 vaccination for cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002932
Abstract: SARS-CoV-2 infection and the resulting COVID-19 have afflicted millions of people in an ongoing worldwide pandemic. Safe and effective vaccination is needed urgently to protect not only the general population but also vulnerable subjects such… read more here.
Keywords: mrna based; patients cancer; based sars; cancer ... See more keywords
Abstract 4154: mRNA-based immunotherapies to treat women's cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4154
Abstract: With its ability to potentially code for any given protein, peptide and fragments, synthetic mRNA has landed itself a broad range of cancer immunotherapy applications, including costimulatory receptors, therapeutic antibodies, vaccines, and cytokines able to… read more here.
Keywords: mrna; immunotherapies treat; based immunotherapies; mrna based ... See more keywords
Incidence, Clinical Presentation, and Management of Myocarditis following mRNA-Based Covid-19 Vaccines: A Brief Report
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DOI: 10.1159/000522216
Abstract: Background: Recent surveillance studies following nationwide mass vaccination are investigating rare complications such as myocarditis, pericarditis, and thromboembolic events related to mRNA-based Covid-19 vaccines. Summary: In the current report, we present an overview of the… read more here.
Keywords: myocarditis; incidence clinical; clinical presentation; covid vaccines ... See more keywords
Modified mRNA-Based Vaccines Against Coronavirus Disease 2019
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DOI: 10.1177/09636897221090259
Abstract: The pandemic of coronavirus disease 2019 (COVID-19) continuously causes deaths worldwide, representing a considerable challenge to health care and economic systems with a new precedent in human history. Many therapeutic medicines primarily focused on preventing… read more here.
Keywords: modrna vaccines; coronavirus disease; mrna based; modified mrna ... See more keywords