A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63392-4
Abstract: The interaction of host and Ebola virus (EBOV) proteins is required for establishing infection. In this study, we use proximity-dependent biotinylation to identify cellular proteins that bind to EBOV proteins encoded by six of the… read more here.
Keywords: decapping complex; scaffold protein; protein; mrna decapping ... See more keywords
Control of mRNA decapping by autoinhibition
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky233
Abstract: Abstract 5′ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are well-studied, the role of abundant intrinsically disordered regions (IDRs) is… read more here.
Keywords: decapping autoinhibition; control; control mrna; mrna decapping ... See more keywords
Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.1101/2023.09.04.556219
Abstract: The mRNA 5’-cap structure removal by the decapping enzyme DCP2 is a critical step in gene regulation. While DCP2 is the catalytic subunit in the decapping complex, its activity is strongly enhanced by multiple factors,… read more here.
Keywords: human dcp1; dcp1a dcp1b; dcp1; mrna decapping ... See more keywords
Eukaryotic mRNA Decapping Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.832547
Abstract: The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation. Enzyme-directed hydrolysis of the cap (decapping) decisively affects mRNA expression and turnover, and is… read more here.
Keywords: mrna decapping; eukaryotic mrna; activation; decapping activation ... See more keywords
mRNA Decapping and 5′-3′ Decay Contribute to the Regulation of ABA Signaling in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.00312
Abstract: Defects in RNA processing and degradation pathways often lead to developmental abnormalities, impaired hormonal signaling and altered resistance to abiotic and biotic stress. Here we report that components of the 5′-3′ mRNA decay pathway, DCP5,… read more here.
Keywords: regulation aba; aba signaling; decapping decay; mrna decapping ... See more keywords
Selective Destabilization of Transcripts by mRNA Decapping Regulates Oocyte Maturation and Innate Immunity Gene Expression during Ageing in C. elegans
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020171
Abstract: Simple Summary In eukaryotes, the elimination of the protective cap from 5′ end of messenger RNA (mRNA) by the decapping complex is an important mechanism of mRNA decay and translation, affecting several cellular processes. In… read more here.
Keywords: immunity; expression; innate immunity; gene expression ... See more keywords
Overexpression of mRNA-decapping enzyme 1a affects survival rate in colorectal carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.8730
Abstract: Processing bodies (P-bodies) are one of the most well understood types of RNA granules, and are associated with a variety of diseases, including cancer. mRNA-decapping enzyme 1a (DCP1a), which may be used as a marker… read more here.
Keywords: dcp1a; carcinoma; colorectal carcinoma; mrna decapping ... See more keywords