Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk—A re‐analysis of eight GWASs
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22585
Abstract: Purpose: mRNA degradation is an important regulatory step for controlling gene expression and cell functions. Genetic abnormalities involved in mRNA degradation genes were found to be associated with cancer risks. Therefore, we systematically investigated the… read more here.
Keywords: analysis; cancer risk; mrna degradation; lung cancer ... See more keywords
m6A RNA Modification Determines Cell Fate by Regulating mRNA Degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular reprogramming"
DOI: 10.1089/cell.2016.0041
Abstract: Emerging evidence suggests that epitranscriptional modifications influence multiple cellular processes. N6-methyladenosine (m6A), as the most abundant reversible methylation of mRNA, has also been reported to play critical roles in modulating embryonic stem cell differentiation and… read more here.
Keywords: m6a rna; mrna degradation; cell fate; m6a ... See more keywords
CRISPR-associated type V proteins as a tool for controlling mRNA stability in S. cerevisiae synthetic gene circuits
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1270
Abstract: Abstract Type V-A CRISPR-(d)Cas system has been used in multiplex genome editing and transcription regulation in both eukaryotes and prokaryotes. However, mRNA degradation through the endonuclease activity of Cas12a has never been studied. In this… read more here.
Keywords: mrna stability; mrna degradation; gene circuits; synthetic gene ... See more keywords
When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad104
Abstract: Abstract mRNA sits at the crossroads of transcription, translation and mRNA degradation. Many questions remain about the coupling of these three processes in Escherichia coli and, in particular, how translation may have an effect on… read more here.
Keywords: elongation; transcription; mrna; mrna degradation ... See more keywords
Dihydroartemisinin-induced mitochondrial mRNA degradation and apoptosis in keloid fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001860
Abstract: Sichuan 610041, China; Department of Occupational Diseases, The Second Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital, Chengdu, Sichuan 610051, China; Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China; Department… read more here.
Keywords: dihydroartemisinin induced; induced mitochondrial; mrna degradation; mitochondrial mrna ... See more keywords
Decreased Expression of Stable RNA Can Alleviate the Lethality Associated with RNase E Deficiency in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00724-16
Abstract: ABSTRACT The endoribonuclease RNase E participates in mRNA degradation, rRNA processing, and tRNA maturation in Escherichia coli, but the precise reasons for its essentiality are unclear and much debated. The enzyme is most active on… read more here.
Keywords: escherichia coli; rnase; rna; mrna degradation ... See more keywords
MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1058726
Abstract: Amplification of the MYCN gene leads to its overexpression at both the mRNA and protein levels. Overexpression of MYCN mRNA may also have an important role in promoting neuroblastoma (NB) beyond the translation of MYCN… read more here.
Keywords: mycn amplified; mrna degradation; mycn mrna; mycn ... See more keywords
Viral-Mediated mRNA Degradation for Pathogenesis
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DOI: 10.3390/biomedicines6040111
Abstract: Cellular RNA decay machinery plays a vital role in regulating gene expression by altering the stability of mRNAs in response to external stresses, including viral infection. In the primary infection, viruses often conquer the host… read more here.
Keywords: infection; pathogenesis; viral mediated; mrna degradation ... See more keywords
sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.23602
Abstract: Post-transcriptional control by small regulatory RNA (sRNA) is critical for rapid adaptive processes. sRNAs can directly modulate mRNA degradation in Proteobacteria without interfering with translation. However, Firmicutes have a fundamentally different set of ribonucleases for… read more here.
Keywords: srna mediated; expression; degradation; mrna degradation ... See more keywords