mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800335
Abstract: The encapsulation of mRNA in nanosystems as gene vaccines for immunotherapy purposes has experienced an exponential increase in recent years. Despite the many advantages envisaged within these approaches, their application in clinical treatments is still… read more here.
Keywords: delivery system; presenting cells; mrna delivery; system targeting ... See more keywords
Bridging mRNA and Polycation using RNA Oligonucleotide Derivatives Improves the Robustness of Polyplex Micelles for Efficient mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102016
Abstract: Polyplex for mRNA delivery requires strong yet reversible association between mRNA and polycation for extracellular robustness and selective intracellular disintegration. Herein, RNA oligonucleotide (OligoRNA) derivatives that bridge mRNA and polycation are developed to stabilize polyplex… read more here.
Keywords: polyplex micelles; mrna delivery; rna oligonucleotide; polycation ... See more keywords
A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205475
Abstract: Messenger RNA (mRNA)‐based therapies offer enhanced control over the production of therapeutic proteins for many diseases. Their clinical implementation warrants formulations capable of delivering them safely and effectively to target sites. Owing to their chemical… read more here.
Keywords: nanoparticle formulation; delivery; mrna delivery; polymeric nanoparticle ... See more keywords
A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301929
Abstract: Ionizable lipid-based nanoparticles (LNPs) are the most advanced non-viral drug delivery systems for RNA therapeutics and vaccines. However, cell type-specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel therapeutic modalities.… read more here.
Keywords: type specific; delivery; mrna delivery; cell type ... See more keywords
Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c01784
Abstract: Lipid nanoparticles (LNPs) carrying therapeutic mRNAs hold great promise in treating lung-associated diseases like viral infections, tumors, and genetic disorders. However, because of their thermodynamically unstable nature, traditional LNPs carrying mRNAs need to be stored… read more here.
Keywords: specific mrna; mrna delivery; lung specific; lung ... See more keywords
Engineered Design of a Mesoporous Silica Nanoparticle-Based Nanocarrier for Efficient mRNA Delivery in Vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c04486
Abstract: We have developed tailor-designed mesoporous silica nanoparticles (MSNPs) specifically for delivering mRNA. Our unique assembly protocol involves premixing mRNA with a cationic polymer and then electrostatically binding it to the MSNP surface. Since the key… read more here.
Keywords: mesoporous silica; engineered design; mrna delivery; design mesoporous ... See more keywords
Ionizable Lipid Nanoparticle Mediated mRNA Delivery for Human CAR T Cell Engineering.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b04246
Abstract: CAR T cell therapy relies on the ex vivo manipulation of patient T cells to create a potent, cancer-targeting therapy, shown to be capable of inducing remission in patients with acute lymphoblastic leukemia and large… read more here.
Keywords: car cell; cell engineering; mrna delivery; cell ... See more keywords
Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10670
Abstract: Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends… read more here.
Keywords: mrna delivery; iterative design; intramuscular mrna; ionizable lipids ... See more keywords
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12893
Abstract: Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nonviral platform for mRNA delivery. While they have been explored for applications including vaccines and gene editing, LNPs have not been investigated for placental insufficiency during… read more here.
Keywords: mrna delivery; placenta; ionizable lipid; pregnancy ... See more keywords
RGD peptide-based lipids for targeted mRNA delivery and gene editing applications
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02771b
Abstract: mRNA therapeutics are promising platforms for protein replacement therapies and gene editing technologies. When delivered via non-viral gene delivery systems, such as lipid nanoparticles (LNPs), mRNA therapeutics are easy to produce and show low toxicity… read more here.
Keywords: mrna delivery; rgd; gene editing; targeted mrna ... See more keywords
Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly
Sign Up to like & getrecommendations! Published in 2023 at "Science and Technology of Advanced Materials"
DOI: 10.1080/14686996.2023.2170164
Abstract: ABSTRACT Messenger RNA (mRNA) therapeutics have recently demonstrated high clinical potential with the accelerated approval of SARS-CoV-2 vaccines. To fulfill the promise of unprecedented mRNA-based treatments, the development of safe and efficient carriers is still… read more here.
Keywords: block catiomers; peg pgtyr; mrna delivery; block ... See more keywords