Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA‐Displayed Peptide Libraries
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DOI: 10.1002/cbic.202100685
Abstract: DNA‐encoded small‐molecule libraries and mRNA displayed peptide libraries both use numerically large pools of oligonucleotide‐tagged molecules to identify potential hits for protein targets. They differ dramatically, however, in the ‘drug‐likeness’ of the molecules that each… read more here.
Keywords: encoded small; mrna displayed; displayed peptide; dna encoded ... See more keywords