Resolving the mRNA Encapsulation-Release Trade-off via Compensatory Forces in Engineered Ionizable Lipids.
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DOI: 10.1002/adma.202512235
Abstract: A critical challenge in lipid nanoparticle (LNP) delivery of messenger RNA (mRNA) is the inherent trade-off between stable encapsulation and efficient intracellular release. Here, this challenge is addressed through rationally engineering compensatory forces between mRNA… read more here.
Keywords: trade; release; mrna encapsulation; encapsulation ... See more keywords