The human ribosome can interact with the abasic site in mRNA via a specific peptide of the uS3 protein located near the mRNA entry channel.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2018.12.015
Abstract: The small subunit ribosomal protein uS3 is a critically important player in the ribosome-mRNA interactions during translation and has numerous functions not directly related to protein synthesis in eukaryotes. A peculiar feature of the human… read more here.
Keywords: protein; near mrna; mrna entry; us3 protein ... See more keywords
Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit
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DOI: 10.1038/s41467-024-50672-8
Abstract: Translation is regulated mainly in the initiation step, and its dysregulation is implicated in many human diseases. Several proteins have been found to regulate translational initiation, including Pdcd4 (programmed cell death gene 4). Pdcd4 is… read more here.
Keywords: mrna entry; 40s small; suppressor protein; pdcd4 ... See more keywords
Dynamics of mRNA entry into stress granules
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DOI: 10.1038/s41556-019-0278-5
Abstract: Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface… read more here.
Keywords: stress granules; entry stress; mrna entry; stress ... See more keywords
eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions
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DOI: 10.3389/fmolb.2021.787664
Abstract: Translation initiation in eukaryotes is a multi-step pathway and the most regulated phase of translation. Eukaryotic initiation factor 3 (eIF3) is the largest and most complex of the translation initiation factors, and it contributes to… read more here.
Keywords: untranslated regions; mrnas long; entry channel; eif3 complex ... See more keywords