Temporal and spatial regulation of mRNA export: Single particle RNA‐imaging provides new tools and insights
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600124
Abstract: The transport of messenger RNAs (mRNAs) from the nucleus to cytoplasm is an essential step in the gene expression program of all eukaryotes. Recent technological advances in the areas of RNA‐labeling, microscopy, and sequencing are… read more here.
Keywords: export; mrna export; regulation mrna; spatial regulation ... See more keywords
Direct Visualization of Individual mRNA Export through Differential Fluorescent Labeling
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1172
Abstract: The nuclear export of mRNA through the nuclear pore complex is a crucial step in gene expression and is tightly regulated through signal-recognizing proteins. Though the mRNAs in the cytoplasm are well imaged in fixed… read more here.
Keywords: export; mrna export; direct visualization; fluorescent labeling ... See more keywords
Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.02.050
Abstract: The RNA helicase DEAD-box protein Sub2 (yeast)/UAP56 (mammals) is conserved across eukaryotes and is essential for mRNA export in trypanosomes. Despite the high conservation of Sub2 in lower eukaryotes such as Trypanosoma cruzi, the low… read more here.
Keywords: tcsub2; mrna export; activity; atpase activity ... See more keywords
Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology"
DOI: 10.1017/s0031182021000068
Abstract: Abstract Abstract The passage of mRNAs through the nuclear pores into the cytoplasm is essential in all eukaryotes. For regulation, mRNA export is tightly connected to the full machinery of nuclear mRNA processing, starting at… read more here.
Keywords: nuclear mrna; mrna processing; export; mrna export ... See more keywords
Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33379-x
Abstract: The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment… read more here.
Keywords: export; mrna export; alyref uif; adaptors alyref ... See more keywords
Regulation of mRNA export through API5 and nuclear FGF2 interaction
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa335
Abstract: Abstract API5 (APoptosis Inhibitor 5) and nuclear FGF2 (Fibroblast Growth Factor 2) are upregulated in various human cancers and are correlated with poor prognosis. Although their physical interaction has been identified, the function related to… read more here.
Keywords: export; mrna export; api5 nuclear; fgf2 interaction ... See more keywords
Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx158
Abstract: Abstract Transcription-export complex 2 (TREX-2, or THSC) facilitates localization of actively transcribing genes such as GAL1 to the nuclear periphery, contributes to the generation of export-competent mRNPs and influences gene expression through interactions with Mediator.… read more here.
Keywords: export; mrna export; structure sac3; sac3 rna ... See more keywords
Genome-wide mapping of infection-induced SINE RNAs reveals a role in selective mRNA export
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx180
Abstract: Abstract Short interspersed nuclear elements (SINEs) are retrotransposons evolutionarily derived from endogenous RNA Polymerase III RNAs. Though SINE elements have undergone exaptation into gene regulatory elements, how transcribed SINE RNA impacts transcriptional and post-transcriptional regulation… read more here.
Keywords: mrna export; infection; rna; rna polymerase ... See more keywords
Abstract 6100: The Fanconi Anemia pathway protein complex FANCI/FANCD2 couples the DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6100
Abstract: Background: Fanconi Anemia (FA) is a rare genetic disease characterized by bone marrow failure and cancer susceptibility. FA gene mutations are also widespread somatically in non-FA cancer patients. While the FA pathway participates in DNA… read more here.
Keywords: mrna export; dna damage; regulation; export ... See more keywords
A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.
Sign Up to like & getrecommendations! Published in 2017 at "RNA"
DOI: 10.1261/rna.060137.116
Abstract: The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are… read more here.
Keywords: export; mrna export; nuclear recycling; eif4e ... See more keywords
Nuclear mRNA Export and Aging
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105451
Abstract: The relationship between transcription and aging is one that has been studied intensively and experimentally with diverse attempts. However, the impact of the nuclear mRNA export on the aging process following its transcription is still… read more here.
Keywords: nuclear mrna; transcription; mrna export; export aging ... See more keywords