Defining a microRNA‐mRNA interaction map for calcineurin inhibitor induced nephrotoxicity
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DOI: 10.1111/ajt.14503
Abstract: Calcineurin inhibitors induce nephrotoxicity through poorly understood mechanisms thereby limiting their use in transplantation and other diseases. Here we define a microRNA (miRNA)‐messenger RNA (mRNA) interaction map that facilitates exploration into the role of miRNAs… read more here.
Keywords: mrna interaction; interaction map; calcineurin; induced nephrotoxicity ... See more keywords
Transcriptome sequencing reveals a lncRNA–mRNA interaction network in extramammary Paget’s disease
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DOI: 10.1186/s12920-021-01135-2
Abstract: Background Extramammary Paget’s disease (EMPD) is a rare malignant intraepidermal adenocarcinoma that is poorly understood. Regulatory long noncoding RNAs (lncRNAs) are characterized in many species and shown to be involved in processes such as development… read more here.
Keywords: interaction network; lncrna mrna; network; extramammary paget ... See more keywords
The CAR–mRNA Interaction Surface Is a Zipper Extension of the Ribosome A Site
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DOI: 10.3390/ijms23031417
Abstract: The ribosome CAR interaction surface behaves as an extension of the decoding center A site and has H-bond interactions with the +1 codon, which is next in line to enter the A site. Through molecular… read more here.
Keywords: interaction; interaction surface; car mrna; car ... See more keywords
In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules
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DOI: 10.3390/molecules23123124
Abstract: Protein-RNA interactions (PRIs) control pivotal steps in RNA biogenesis, regulate multiple physiological and pathological cellular networks, and are emerging as important drug targets. However, targeting of specific protein-RNA interactions for therapeutic developments is still poorly… read more here.
Keywords: protein mrna; mrna interaction; cellulo protein; molecules cellulo ... See more keywords