mRNA Lipoplexes with Cationic and Ionizable α-Amino-lipophosphonates: Membrane Fusion, Transfection, mRNA Translation and Conformation
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DOI: 10.3390/pharmaceutics14030581
Abstract: Cationic liposomes are attractive carriers for mRNA delivery. Here, mRNA lipoplexes (LX) were prepared with the cationic lipids α-aminolipophosphonate (3b) or imidazolium lipophosphoramidate (2) associated with various α-aminolipophosphonates co-lipids comprising protonable groups (imidazole or pyridine)… read more here.
Keywords: membrane fusion; mrna lipoplexes; mrna translation; translation ... See more keywords
Efficient mRNA Delivery with mRNA Lipoplexes Prepared Using a Modified Ethanol Injection Method
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DOI: 10.3390/pharmaceutics15041141
Abstract: Messenger RNA (mRNA)-based therapies are a novel class of therapeutics used in vaccination and protein replacement therapies for monogenic diseases. Previously, we developed a modified ethanol injection (MEI) method for small interfering RNA (siRNA) transfection,… read more here.
Keywords: modified ethanol; method; ethanol injection; mrna lipoplexes ... See more keywords