Beyond the Endosomal Bottleneck: Understanding the Efficiency of mRNA/LNP Delivery
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202404510
Abstract: The development of lipid nanoparticles (LNP) holds great promise for vaccine and therapeutic applications. However, ineffective transport of nucleic acid cargo from endosomes to the cytosol, termed “endosomal escape,” has remained a bottleneck to achieving… read more here.
Keywords: mrna lnp; efficiency; delivery; lnp ... See more keywords
Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.70078
Abstract: mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle… read more here.
Keywords: mrna lnp; therapy; medicine; metabolic diseases ... See more keywords
An mRNA vaccine encoding five conserved Group A Streptococcus antigens
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60580-0
Abstract: A commercial vaccine to address the high global burden of Group A Streptococcus (GAS) disease is an urgent and unmet medical need. Messenger RNA (mRNA) lipid-nanoparticle (LNP) vaccines represent a largely untapped platform for targeting… read more here.
Keywords: mrna lnp; group streptococcus; gas; vaccine ... See more keywords
A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine models
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01244-4
Abstract: Staphylococcus aureus has been posing a significant global health threat, underscoring an urgent need for innovative preventive strategies, notably vaccines. This study presents an evaluation of a multi-target mRNA vaccine against S. aureus, engineered to… read more here.
Keywords: mrna lnp; vaccine; cocktail; staphylococcus aureus ... See more keywords
To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01283-x
Abstract: G protein-coupled receptors (GPCRs) are key therapeutic targets for various diseases, such as the thrombin receptor protease-activated receptor 4 (PAR4) involved in thrombotic cardiovascular disorders. However, the structural complexity of native GPCRs hinders recombinant protein… read more here.
Keywords: par4; receptor; mrna lnp; par4 mrna ... See more keywords
mRNA encoding bone morphogenetic protein-2 facilitated peri-implant bone formation of titanium implants placed in rat femurs
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-02931-x
Abstract: This study evaluated the effectiveness of N1-methylpseudouridine-modified mRNA encoding bone morphogenetic protein-2 (BMP-2 mRNA-LNP) in promoting bone growth and improving titanium implant integration in rat femur bone defects. Sixteen Sprague-Dawley rats (32 femurs) were used,… read more here.
Keywords: mrna lnp; titanium; bmp mrna; group ... See more keywords
Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr06858j
Abstract: mRNA lipid nanoparticles (LNPs) are at the forefront of nucleic acid intracellular delivery, as exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 vaccines. The success of an LNP product largely depends on… read more here.
Keywords: high throughput; mrna lnp; throughput; throughput platform ... See more keywords
TMIC-120. Investigating EGFRvIII mRNA LNP vaccine-induced re-programming of the GBM TME using the 10x Genomics Visium HD platform
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1873
Abstract: Glioblastoma (GBM) is a lethal brain tumor refractory to standard therapies, highlighting the need for alternative treatments. Immunotherapies, particularly cancer vaccines targeting neoantigens, offer a compelling approach to enhance anti-tumor immunity. To this end, we… read more here.
Keywords: egfrviii mrna; mrna lnp; gbm; tumor ... See more keywords
Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01723-22
Abstract: This study shows that the nucleoside-modified mRNA-LNP vaccine platform is a promising alternative for egg-based influenza vaccines. We show that mRNA-LNP vaccines expressing H3 antigens elicit high levels of antibodies in mice and protect against… read more here.
Keywords: egg; nucleoside modified; egg based; modified mrna ... See more keywords
PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge
Sign Up to like & getrecommendations! Published in 2024 at "mBio"
DOI: 10.1128/mbio.02958-23
Abstract: ABSTRACT Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causes severe diarrhea in neonatal piglets, which is associated with a high mortality rate. Thus, developing effective and safe vaccines remains a top priority for… read more here.
Keywords: mrna lnp; spike protein; mrna vaccine; pedv spike ... See more keywords
Abstract 1321: In vivo immune cell programming using mRNA-LNP chimeric antigen receptors
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1321
Abstract: Introduction: The tumor microenvironment (TME) is a dynamic and multifaceted system that comprises largely myeloid lineage immune cells including monocytes, neutrophils, macrophages, and dendritic cells. Reprogramming the myeloid compartment within the context of cancer therapy… read more here.
Keywords: myeloid cells; mrna lnp; car; tumor ... See more keywords