Replacing PEG-Lipid with Amphiphilic Polycarbonates in mRNA-Loaded Lipid Nanoparticles: Impact of Polycarbonate Structure on Physicochemical and Transfection Properties.
Sign Up to like & getrecommendations! Published in 2025 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.5c00088
Abstract: Since the remarkable breakthrough of COVID-19 mRNA vaccines, lipid nanoparticles (LNPs) have gained substantial attention as the most cutting-edge clinical formulations for mRNA delivery. PEGylated lipid (PEG-lipid) has been regarded as an essential constituent of… read more here.
Keywords: mrna loaded; structure; transfection; lipid nanoparticles ... See more keywords
Coarse-Grained Simulation of mRNA-Loaded Lipid Nanoparticle Self-Assembly.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c00216
Abstract: Ionizable lipid-containing lipid nanoparticles (LNPs) have enabled the delivery of RNA for a range of therapeutic applications. In order to optimize safe, targeted, and effective LNP-based RNA delivery platforms, an understanding of the role of… read more here.
Keywords: mrna loaded; coarse grained; grained simulation; simulation mrna ... See more keywords
Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.5c09800
Abstract: Lipid nanoparticles (LNPs) are the leading platform for delivering nucleic acid therapeutics, produced by rapidly mixing lipids in ethanol with nucleic acid cargo in an aqueous buffer. LNP production is often approached with a mixing-focused… read more here.
Keywords: method; mrna loaded; control; size morphology ... See more keywords
206 Engineering MRNA-Loaded Immunogenic Exosomes for Targeted Glioblastoma Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Neurosurgery"
DOI: 10.1227/neu.0000000000003360_206
Abstract: INTRODUCTION: Recent advancements in mRNA therapeutics have shown remarkable efficacy against pathogenic infections, prompting interest in their application for other diseases, particularly cancer. However, one major challenge is the precise delivery of genetic material to… read more here.
Keywords: mrna loaded; mrna; delivery; engineering mrna ... See more keywords
mRNA-Loaded Lipid Nanoparticles Targeting Immune Cells in the Spleen for Use as Cancer Vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15081017
Abstract: mRNA delivery has recently gained substantial interest for possible use in vaccines. Recently approved mRNA vaccines are administered intramuscularly where they transfect antigen-presenting cells (APCs) near the site of administration, resulting in an immune response.… read more here.
Keywords: cells spleen; targeting immune; mrna loaded; immune cells ... See more keywords