Testing Models of mRNA Localization Reveals Robustness Regulated by Reducing Transport between Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.10.025
Abstract: Robust control of gene expression in both space and time is of central importance in the regulation of cellular processes and for multicellular development. However, the mechanisms by which robustness is achieved are generally not… read more here.
Keywords: transport; mrna localization; overexpression mutant; model ... See more keywords
SnapShot: Subcellular mRNA Localization
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.004
Abstract: Many cells localize mRNAs to discrete locations in the cytoplasm. Coupled to local translation, this process affords precise spatial and temporal control of protein function. This SnapShot provides an overview of the key events in… read more here.
Keywords: subcellular mrna; snapshot subcellular; mrna localization;
Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1806189115
Abstract: Significance De novo protein synthesis in neuronal axons plays important roles in neural circuit formation, maintenance, and disease. Key to the selectivity of axonal protein synthesis is whether an mRNA is present at the right… read more here.
Keywords: actin mrna; mrna localization; mrna trafficking; mrna ... See more keywords
Mitochondrial mRNA localization is governed by translation kinetics and spatial transport
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2022.02.16.480701
Abstract: For many nuclear-encoded mitochondrial genes, mRNA localizes to the mitochondrial surface co-translationally, aided by the association of a mitochondrial targeting sequence (MTS) on the nascent peptide with the mitochondrial import complex. For a subset of… read more here.
Keywords: translation kinetics; mrna localization; localization; mrna types ... See more keywords
Far from home: the role of glial mRNA localization in synaptic plasticity
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079422.122
Abstract: Neurons and glia are highly polarized cells, whose distal cytoplasmic functional subdomains require specific proteins. Neurons have axonal and dendritic cytoplasmic extensions containing synapses whose plasticity is regulated efficiently by mRNA transport and localized translation.… read more here.
Keywords: mrna localization; far home; localized translation; plasticity ... See more keywords
Phosphorylation controls the oligomeric state of She2 and mRNA localization in yeast
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079555.122
Abstract: Messenger RNA (mRNA) localization is an important mechanism controlling local protein synthesis. In budding yeast, asymmetric localization of transcripts such as ASH1 mRNA to the bud tip depends on the She2 RNA-binding protein. She2 assembles… read more here.
Keywords: phosphorylation controls; mrna localization; localization; she2 ... See more keywords
mRNA Localization to the Endoplasmic Reticulum in Plant Endosperm Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113511
Abstract: Subcellular mRNA localization is an evolutionarily conserved mechanism to spatially and temporally drive local translation and, in turn, protein targeting. Hence, this mechanism achieves precise control of gene expression and establishes functional and structural networks… read more here.
Keywords: endoplasmic reticulum; mrna localization; localization; localization endoplasmic ... See more keywords
Optimization of RNA In Situ Hybridization for mRNA Localization Detection in Mature Tissue of Cucumber Seedlings
Sign Up to like & getrecommendations! Published in 2020 at "Plants"
DOI: 10.3390/plants9111461
Abstract: Cucumber (Cucumis sativus L.) is one of the main vegetable crops in China. The physiological cultivation mechanism and gene function characteristics of cucumber are of great significance to the construction of modern agriculture. Due to… read more here.
Keywords: mature tissue; mrna localization; situ hybridization; hybridization ... See more keywords