Disparate genes come together: Spatial and genetic screens point to disruptions in vesicle trafficking and mRNA metabolism in synucleinopathies
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26985
Abstract: a-Synuclein (asyn) is the primary component of proteinaceous aggregates that pathologically define a category of diseases termed synucleinopathies, which includes Parkinson’s disease (PD) and dementia with Lewy bodies. Elucidating the native function and pathway involvement… read more here.
Keywords: protein; disparate genes; spatial genetic; vesicle trafficking ... See more keywords
Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism
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DOI: 10.1371/journal.pone.0192633
Abstract: The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of proteins involved in mRNA maturation, translation,… read more here.
Keywords: metabolism; uncover widespread; conservation; multispecies reconstructions ... See more keywords
mRNA Metabolism and Hypertension
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DOI: 10.3390/biomedicines11010118
Abstract: Hypertension is the most frequent cardiovascular risk factor all over the world. It remains a leading contributor to the risk of cardiovascular events and death. In the year 2015, about 1.5 billion of adult people… read more here.
Keywords: metabolism; metabolism hypertension; mrna metabolism; hypertension ... See more keywords