Effective mRNA Protection by Poly(L-Ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer Toward Maximizing mRNA Introduction Efficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202100754
Abstract: For efficient delivery of messenger (m)RNA, delivery carriers need two major functions: protecting mRNA from nucleases and translocating mRNA from endolysosomes to the cytoplasm. Herein, these two complementary functionalities were integrated into a single polyplex… read more here.
Keywords: mrna polyplex; endosomal escape; charge conversion; poly ornithine ... See more keywords