Genome‐wide screening of potential RNase Y‐processed mRNAs in the M49 serotype Streptococcus pyogenes NZ131
Sign Up to like & getrecommendations! Published in 2019 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.671
Abstract: RNase Y is a major endoribonuclease in Group A streptococcus (GAS) and other Gram‐positive bacteria. Our previous study showed that RNase Y was involved in mRNA degradation and processing in GAS. We hypothesized that mRNA… read more here.
Keywords: streptococcus pyogenes; mrna processing; rnase processed; rnase ... See more keywords
A potential mechanism underlying U1 snRNP inhibition of the cleavage step of mRNA 3' processing.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.092
Abstract: It is well established that U1 snRNP inhibits the cleavage of cryptic polyadenylation site (PAS) within introns, thereby facilitating full-length mRNA transcription for numerous genes in vertebrate cells, yet the underlying mechanism remains poorly understood.… read more here.
Keywords: mrna processing; cleavage step; mechanism; step mrna ... See more keywords
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.12.023
Abstract: Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is dynamically regulated. Here, we investigate when in their life cycle mRNAs become pseudouridylated to illuminate the potential regulatory functions of endogenous mRNA… read more here.
Keywords: pseudouridine synthases; pre; mrna processing; pre mrna ... See more keywords
Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology"
DOI: 10.1017/s0031182021000068
Abstract: Abstract Abstract The passage of mRNAs through the nuclear pores into the cytoplasm is essential in all eukaryotes. For regulation, mRNA export is tightly connected to the full machinery of nuclear mRNA processing, starting at… read more here.
Keywords: nuclear mrna; mrna processing; export; mrna export ... See more keywords
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0424-1
Abstract: The post-genomic era has seen many advances inBaryza and G. Rice for helpful our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to target even monogenic tumors. Here, we combine phenotypic… read more here.
Keywords: mrna processing; ewing sarcoma; cpsf3; aml ewing ... See more keywords
Analysis of mRNA processing at whole transcriptome level, transcriptomic profile and genome sequence refinement of Trypanosoma cruzi
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53924-6
Abstract: The genomic sequence of Trypanosoma cruzi, the protozoan causative of Chagas disease was published more than a decade ago. However, due to their complexity, its complete haploid predicted sequence and therefore its genetic repertoire remains… read more here.
Keywords: mrna processing; cruzi; genome; sequence ... See more keywords
Specific processing of meiosis-related transcript is linked to final maturation in human oocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaad021
Abstract: Human meiosis in oocytes entails an intricate regulation of the transcriptome to support late oocyte growth and early embryo development, both crucial to reproductive success. Currently, little is known about the co- and post-transcriptional mRNA… read more here.
Keywords: maturation; meiosis; meiosis related; human oocytes ... See more keywords
Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac338
Abstract: Abstract Efficient splicing requires a balance between high-fidelity splice-site (SS) selection and speed. In Saccharomyces cerevisiae, Pre-mRNA processing factor 8 (Prp8) helps to balance precise SS selection and rapid, efficient intron excision and exon joining.… read more here.
Keywords: processing factor; fidelity; alleles arabidopsis; pre mrna ... See more keywords
Landscape of pathogenic variants in six pre-mRNA processing factor genes for retinitis pigmentosa based on large in-house data sets and database comparisons.
Sign Up to like & getrecommendations! Published in 2022 at "Acta ophthalmologica"
DOI: 10.1111/aos.15104
Abstract: PURPOSE Variants in six genes encoding pre-mRNA processing factors (PRPFs) are a common cause of autosomal dominant retinitis pigmentosa (ADRP). This study aims to determine the characteristics of potential pathogenic variants (PPVs) in the six… read more here.
Keywords: pre mrna; retinitis pigmentosa; ppvs; house ... See more keywords
Pre-mRNA processing includes N6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of "RNA epigenetics".
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.065219.117
Abstract: By using a cell fraction technique that separates chromatin-associated nascent RNA, newly completed nucleoplasmic mRNA and cytoplasmic mRNA, we have shown in a previous study that residues in exons are methylated (m6A) in nascent pre-mRNA… read more here.
Keywords: mrna processing; methylation; mrna exons; pre mrna ... See more keywords
ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing
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DOI: 10.1371/journal.pgen.1009439
Abstract: ELAV/Hu factors are conserved RNA binding proteins (RBPs) that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago. Nevertheless, little was… read more here.
Keywords: mrna processing; binding proteins; elav factors; elav ... See more keywords