RBM24 is required for mouse hair cell development through regulating pre‐mRNA alternative splicing and mRNA stability
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31003
Abstract: As the sensory receptor cells in vertebrate inner ear and lateral lines, hair cells are characterized by the hair bundle that consists of one tubulin‐based kinocilium and dozens of actin‐based stereocilia on the apical surface… read more here.
Keywords: hair; mrna stability; hair cell; cell development ... See more keywords
Improving the expression of recombinant pullulanase by increasing mRNA stability in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Electronic Journal of Biotechnology"
DOI: 10.1016/j.ejbt.2017.07.001
Abstract: Abstract Background Pullulanase production in both wild-type strains and recombinantly engineered strains remains low. The Shine-Dalgarno (SD) sequence and stem-loop structure in the 5′ or 3′ untranslated region (UTR) are well-known determinants of mRNA stability.… read more here.
Keywords: pullulanase; mrna stability; pula pula; expression ... See more keywords
Fast Translation within the First 45 Codons Decreases mRNA Stability and Increases Premature Transcription Termination in E. coli.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.01.026
Abstract: We show here that the specific use of fast or slowly translated codons in the early coding region of a gene may influence both the mRNA stability and premature transcription termination. We first inserted a… read more here.
Keywords: translation; mrna stability; termination; transcription termination ... See more keywords
NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46144
Abstract: Recruitment of inflammatory cells is a major feature of alcoholic liver injury however; the signals and cellular sources regulating this are not well defined. C-C chemokine receptor type 2 (CCR2) is expressed by active hepatic… read more here.
Keywords: ccr2 ccl2; ccl2 mrna; mrna stability; alcoholic liver ... See more keywords
TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications.
Sign Up to like & getrecommendations! Published in 2021 at "RNA biology"
DOI: 10.1080/15476286.2021.1917185
Abstract: Dendritic cells (DCs) form a sentinel network to induce protective immunity against pathogens or self-tolerance. mRNA stability is an important part of the post-transcriptional regulation (PTR) that controls the maturation and function of DCs. In… read more here.
Keywords: regulation mrna; mrna stability; tolerance; ttp mediated ... See more keywords
Methyltransferase-like 3 induces the development of cervical cancer by enhancing insulin-like growth factor 2 mRNA-binding proteins 3-mediated apoptotic chromatin condensation inducer 1 mRNA stability
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2044261
Abstract: ABSTRACT N6-methyladenosine (m6A) plays a critical role in the tumorigenesis of cervical cancer (CC). Here, we aimed to investigate the potential role of methyltransferase-like 3 (METTL3) in CC. Gene expression was determined via real-time quantitative… read more here.
Keywords: cervical cancer; mrna stability; growth; methyltransferase like ... See more keywords
IGF2BP1 promotes the liver cancer stem cell phenotype by regulating MGAT5 mRNA stability via m6A RNA methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0153
Abstract: The aim of this study was to elucidate the mechanism of action of the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) on the phenotype of the liver cancer stem cells (LCSCs). To gain insight… read more here.
Keywords: mgat5; mrna stability; via m6a; stem ... See more keywords
CRISPR-associated type V proteins as a tool for controlling mRNA stability in S. cerevisiae synthetic gene circuits
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1270
Abstract: Abstract Type V-A CRISPR-(d)Cas system has been used in multiplex genome editing and transcription regulation in both eukaryotes and prokaryotes. However, mRNA degradation through the endonuclease activity of Cas12a has never been studied. In this… read more here.
Keywords: mrna stability; mrna degradation; gene circuits; synthetic gene ... See more keywords
Initiating ribosomes and a 5′/3′-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx793
Abstract: Abstract We previously showed that ribosomes initiating translation of the B. subtilis hbs mRNA at a strong Shine–Dalgarno sequence block the 5′ exoribonuclease RNase J1 from degrading into the coding sequence. Here, we identify new… read more here.
Keywords: mrna stability; hbs mrna; rnase; stability translation ... See more keywords
Codon stabilization coefficient as a metric to gain insights into mRNA stability and codon bias and their relationships with translation
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz033
Abstract: Abstract The codon stabilization coefficient (CSC) is derived from the correlation between each codon frequency in transcripts and mRNA half-life experimental data. In this work, we used this metric as a reference to compare previously… read more here.
Keywords: mrna stability; codon stabilization; codon bias; stability codon ... See more keywords
Methyltransferase‐like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6‐methyladenosine‐dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15658
Abstract: N6‐methyladenosine (m6A) is a highly abundant RNA modification in eukaryotic cells. Methyltransferase‐like 3 (METTL3), a major protein in the m6A methyltransferase complex, plays important roles in many malignancies, but its role in cervical cancer metastasis… read more here.
Keywords: cervical cancer; metastasis; mrna stability; m6a ... See more keywords