The role of mRNA structure in bacterial translational regulation
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DOI: 10.1002/wrna.1370
Abstract: The characteristics of bacterial messenger RNAs (mRNAs) that influence translation efficiency provide many convenient handles for regulation of gene expression, especially when coupled with the processes of transcription termination and mRNA degradation. An mRNA's structure,… read more here.
Keywords: translational regulation; mrna structure; bacterial translational; structure ... See more keywords
Adaptation of mRNA structure to control protein folding
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DOI: 10.1080/15476286.2017.1349047
Abstract: ABSTRACT Comparison of mRNA and protein structures shows that highly structured mRNAs typically encode compact protein domains suggesting that mRNA structure controls protein folding. This function is apparently performed by distinct structural elements in the… read more here.
Keywords: protein; structure control; mrna structure; protein folding ... See more keywords
The importance of mRNA structure in determining the pathogenicity of synonymous and non‐synonymous mutations in haemophilia
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DOI: 10.1111/hae.13107
Abstract: Mutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype–phenotype relationships. Haemophilia is associated with inversions,… read more here.
Keywords: synonymous non; synonymous mutations; mrna structure; structure determining ... See more keywords
Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure.
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DOI: 10.1261/rna.064469.117
Abstract: The impact of inherited and somatic mutations on messenger RNA (mRNA) structure remains poorly understood. Recent technological advances that leverage next-generation sequencing to obtain experimental structure data, such as SHAPE-MaP, can reveal structural effects of… read more here.
Keywords: mrna structure; tpt1 lcp1; structure; shape map ... See more keywords