A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance
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DOI: 10.1080/15476286.2022.2065116
Abstract: ABSTRACT Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising… read more here.
Keywords: stress; ribosome collisions; collisions stress; stress responses ... See more keywords
Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance
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DOI: 10.1261/rna.079416.122
Abstract: Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly compelling for Upf1. Hence, we… read more here.
Keywords: mrna surveillance; ribosome bound; upf1 forms; ribosome ... See more keywords