Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202513720
Abstract: Mitochondrial dysfunction‐mediated ribosomal translation suppression is a hallmark of aging and a major driver of degenerative diseases, limiting mRNA therapy efficacy. Here, ionizable coenzyme Q10 (iCoQ10)‐engineered lipid/fiber microplexes (iCLNP@SF) are developed that restore the mitochondrial‐ribosomal… read more here.
Keywords: mrna; degenerative diseases; translation; mrna therapy ... See more keywords
A new era for rare genetic diseases.
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DOI: 10.1089/hum.2019.090
Abstract: Exogenous delivery of messenger RNA (mRNA) is emerging as a new class of medicine with broad applicability including the potential to treat rare, monogenic disorders. Recent advances in mRNA technology, including modifications to the mRNA… read more here.
Keywords: mrna therapy; new era; therapy; era rare ... See more keywords
Advances and Perspectives of Pharmaceutical Nanotechnology in mRNA therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738510666220825145124
Abstract: read more here.
Keywords: nanotechnology; mrna therapy; advances perspectives; nanotechnology mrna ... See more keywords
mRNA therapy for myocardial infarction: A review of targets and delivery vehicles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1037051
Abstract: Cardiovascular diseases are the leading cause of death in the world. This is partly due to the low regenerative capacity of adult hearts. mRNA therapy is a promising approach under development for cardiac diseases. In… read more here.
Keywords: mrna therapy; therapy myocardial; delivery; myocardial infarction ... See more keywords