Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28230
Abstract: Mammalian cells, particularly Chinese hamster ovary cells, are the dominant system for the production of protein‐based biotherapeutics, however, product degradation, particularly of Fc‐fusion proteins, is sometimes observed that impacts the quality of the protein generated.… read more here.
Keywords: fusion; translation elongation; fusion protein; mrna translation ... See more keywords
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09601-4
Abstract: Clinical surgical practices have found that children who undergo multiple anesthesia may have an increased risk of deficiencies in cognition and fine motor control. Here, we report that YT521-B homology domain family 1 (YTHDF1), a… read more here.
Keywords: anesthesia; mrna translation; motor; fine motor ... See more keywords
Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2018.11.030
Abstract: Summary Local translation regulates the axonal proteome, playing an important role in neuronal wiring and axon maintenance. How axonal mRNAs are localized to specific subcellular sites for translation, however, is not understood. Here we report… read more here.
Keywords: translation platforms; mrna translation; translation; late endosomes ... See more keywords
Targeting mRNA translation in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.04.003
Abstract: Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The exact cause(s) of PD is not well understood, although genetic mutations are associated with some forms of the disease. Many of these mutations,… read more here.
Keywords: targeting mrna; mrna translation; translation; parkinson disease ... See more keywords
Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.03.009
Abstract: Abstract Being both advanced in age and obese each contribute to cardiac hypertrophy in a unique manner. Electron transport complexes I and IV are implicated in deficient electron transport during cardiomyopathies and contain the majority… read more here.
Keywords: obese mice; translation initiation; mrna translation; aged obese ... See more keywords
A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.06.048
Abstract: During neuronal development, local mRNA translation is required for axon guidance and synaptogenesis, and dysregulation of this process contributes to multiple neurodevelopmental and cognitive disorders. However, regulation of local protein synthesis in developing axons remains poorly… read more here.
Keywords: actin; mena; mrna translation; translation ... See more keywords
Regulation of mRNA Translation in Neurons—A Matter of Life and Death
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.09.057
Abstract: Dynamic regulation of mRNA translation initiation and elongation is essential for the survival and function of neural cells. Global reductions in translation initiation resulting from mutations in the translational machinery or inappropriate activation of the… read more here.
Keywords: regulation mrna; death; mrna translation; translation ... See more keywords
Manganese Oxide-Incorporated Hybrid Lipid Nanoparticles Amplify the Potency of mRNA Vaccine via Oxygen Generation and STING Activation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c12166
Abstract: Messenger RNA (mRNA) vaccines have exhibited enormous potential in the treatment of human diseases; however, their widespread applications are curtailed by the induction of reactive oxygen species during mRNA translation, which greatly compromises the translation… read more here.
Keywords: mrna translation; oxygen; mrna vaccine; sting activation ... See more keywords
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13360-6
Abstract: Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK… read more here.
Keywords: melanoma; persister cells; persister; mrna translation ... See more keywords
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58118-5
Abstract: Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose… read more here.
Keywords: cancer; mrna translation; energy; rna quadruplexes ... See more keywords
Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58207-5
Abstract: A key regulatory step in protein synthesis is the initiation of mRNA translation. We developed an efficient, robust, and broadly applicable system for light-induced protein translation to control the production of proteins of interest and… read more here.
Keywords: mrna translation; phosphorodiamidate morpholino; morpholino; control ... See more keywords