Medication‐related osteonecrosis of the jaw: A literature review and update
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DOI: 10.1002/dvg.23500
Abstract: Since the initial description of medication‐related osteonecrosis of the jaw (MRONJ) almost two decades ago, the potential pathophysiology and risk factors have been elaborated on in many investigations and guidelines. However, the definitive pathophysiology based… read more here.
Keywords: medication; medication related; review; related osteonecrosis ... See more keywords
Investigation of Sustained BMP Delivery in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model.
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DOI: 10.1002/mabi.201900226
Abstract: Medication-related osteonecrosis of the jaw (MRONJ) poses an ongoing challenge for clinicians and researchers. Currently, there is a lack of preventative measures available for at-risk patients undergoing tooth extractions, especially those with prior bisphosphonate treatment… read more here.
Keywords: mronj; related osteonecrosis; jaw mronj; delivery ... See more keywords
Current knowledge regarding medication-related osteonecrosis of the jaw among different health professionals
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DOI: 10.1007/s00520-020-05374-4
Abstract: Purpose To assess the current knowledge regarding medication-related osteonecrosis of the jaw (MRONJ); the adverse effects of anti-resorptive (AR) and anti-angiogenic (AA) drugs; strategies for MRONJ prevention and treatment; and perception of the dentist’s role… read more here.
Keywords: mronj; knowledge regarding; knowledge; current knowledge ... See more keywords
Prognosis by cancer type and incidence of zoledronic acid–related osteonecrosis of the jaw: a single-center retrospective study
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DOI: 10.1007/s00520-022-06839-4
Abstract: Survival time after bisphosphonate use has been increasingly recognized to be associated with the incidence of medication-related osteonecrosis of the jaw (MRONJ); however, this has not been elucidated sufficiently in the literature. This study aimed… read more here.
Keywords: cancer; osteonecrosis jaw; prognosis; related osteonecrosis ... See more keywords
Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): A systematic review
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DOI: 10.1016/j.heliyon.2020.e03795
Abstract: A temporary discontinuation (drug holiday) of high-dose antiresorptive (AR) agents has been proposed to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ). The aim of this systematic review was to answer the question:… read more here.
Keywords: dose antiresorptive; drug holiday; mronj; high dose ... See more keywords
Immediate reconstruction of mandibular defect after treatment of medication-related osteonecrosis of the jaw (MRONJ) with rhBMP-2/ACS and miniplate: Review of 3 cases
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DOI: 10.1016/j.ijscr.2019.11.038
Abstract: Highlights • The pathogenesis of MRONJ is related to repression of osteoclast mediated bone remodeling.• rhBMP-2 can stimulate not only osteoblasts but also osteoclasts and induce new bone formation.• ACS has been proved to be… read more here.
Keywords: rhbmp; mronj; rhbmp acs; treatment ... See more keywords
Identifying MRONJ-affected bone with digital fusion of functional imaging (FI) and cone-beam computed tomography (CBCT): case reports and hypothesis.
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DOI: 10.1016/j.oooo.2016.11.007
Abstract: Surgical debridement of medication-related osteonecrosis of the jaw (MRONJ) lesions is far less predictable than lesion resection. Margins for surgical debridement are guided by surrogate markers of bone viability, such as bleeding and bone fluorescence,… read more here.
Keywords: mronj; computed tomography; bone; debridement ... See more keywords
Incidence of and risk factors for medication-related osteonecrosis of the jaw in women with breast cancer with bone metastasis: a population-based study.
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DOI: 10.1016/j.oooo.2020.04.808
Abstract: OBJECTIVE The aim of this study was to prospectively determine the incidence of medication-related osteonecrosis of the jaw (MRONJ) and define risk factors in patients with metastatic breast cancer treated with zoledronic acid and/or denosumab.… read more here.
Keywords: mronj; risk; study; breast cancer ... See more keywords
Surgical Management of Medication-Related Osteonecrosis of the Jaw Patients Related to Dental Implants.
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DOI: 10.1097/scs.0000000000006283
Abstract: OBJECTIVES The aim of the present study is to report a case series of patients with peri-implant medication-related osteonecrosis of the jaw (MRONJ), in particular describing the onset of the condition and surgical treatment outcome.… read more here.
Keywords: osteonecrosis jaw; mronj; treatment; peri implant ... See more keywords
Medication-related osteonecrosis (MRONJ) of the mandible and maxilla
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DOI: 10.1136/bcr-2018-224455
Abstract: In 2003, Marx reported the first case of osteonecrosis of the jaw in 36 cases related to zoledronic acid or pamidronate. Painful bone exposure in the mandible or maxilla unresponsive to medical or surgical management… read more here.
Keywords: mronj; osteonecrosis; related osteonecrosis; maxilla ... See more keywords
The Therapeutic Effectiveness Using Fluorescence-Guided Surgery for MRONJ
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DOI: 10.1155/2022/1650790
Abstract: Background Long-term application of antiresorptive and/or antiangiogenic agents may cause oral disorders, including medication-related osteonecrosis of the jaw (MRONJ), which remains an incurable disease. Surgical treatment can help alleviate infection of the jaw and block… read more here.
Keywords: surgery; bone; resection; mronj ... See more keywords