Impact of combined MRP1 inhibition and mutant p53-targeting compound APR-246.
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DOI: 10.1200/jco.2019.37.15_suppl.e14712
Abstract: e14712 Background: The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. Mutant p53 protein is often expressed at high levels and accompanied with gain-of-function activities that promote tumor development and resistance… read more here.
Keywords: apr 246; p53; mrp1 inhibition; mutant p53 ... See more keywords