In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2160-0
Abstract: PurposeMultidrug resistance-associated protein 2 (MRP2/ABCC2) is an efflux pump that removes drugs and chemicals from cells. We sought to characterize the expression, trafficking and in vitro activity of seven single nucleotide polymorphisms (SNPs) in the… read more here.
Keywords: abcc2; mrp2; transport; mrp2 abcc2 ... See more keywords
Substrate and method dependent inhibition of three ABC‐transporters (MDR1, BCRP, and MRP2)
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.03.002
Abstract: ABSTRACT Drug transport and drug‐drug interactions (DDI) with human ABC transporters are generally investigated in mammalian cell lines or inverted membrane vesicles from insect cells (Sf9) overexpressing the transporter of interest. In this study, we… read more here.
Keywords: abc transporters; mrp2; inhibition; probe substrates ... See more keywords
The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.02.023
Abstract: Dioscorea bulbifera L. (DB) is a traditional Chinese herb used in thyroid disease and cancer. However, the clinical use of DB remains a challenge due to its hepatotoxicity, which is caused, in part, by the… read more here.
Keywords: liver injury; mrp2; dioscorea bulbifera; diob ... See more keywords
Slug Mediates MRP2 Expression in Non-Small Cell Lung Cancer Cells
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DOI: 10.3390/biom12060806
Abstract: Transcriptional factors, such as Snail, Slug, and Smuc, that cause epithelial-mesenchymal transition are thought to regulate the expression of Ezrin, Radixin, and Moesin (ERM proteins), which serve as anchors for efflux transporters on the plasma… read more here.
Keywords: mrp2; lung cancer; slug; transfected cells ... See more keywords