Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.02.011
Abstract: Introduction: Multidrug resistance‐associated protein 3 (MRP3), an efflux transporter on the hepatic basolateral membrane, may function as a compensatory mechanism to prevent the accumulation of anionic substrates (e.g., bile acids) in hepatocytes. Inhibition of MRP3… read more here.
Keywords: inhibition; novel mrp3; mrp3; model ... See more keywords
Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.03.011
Abstract: Sirtuins (SIRTs) 1 and 2 deacetylases are overexpressed in hepatocellular carcinoma (HCC) and are associated with tumoral progression and multidrug resistance (MDR). In this study we analyzed whether SIRTs 1 and 2 activities blockage was… read more here.
Keywords: survival migration; hepatocellular carcinoma; migration; mrp3 ... See more keywords
Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.078329
Abstract: Clopidogrel acyl glucuronide (CLP-G) is a major phase II metabolite of clopidogrel generated in the liver for further excretion into urine; however, it is unclear whether CLP-G transports from hepatocytes into blood. Because multidrug resistance-associated… read more here.
Keywords: clp; acyl glucuronide; mrp3 transports; mrp3 ... See more keywords
The function of multidrug resistance-associated protein 3 in the transport of bile acids under normal physiological and lithocholic acid-induced cholestasis conditions.
Sign Up to like & getrecommendations! Published in 2021 at "Current drug metabolism"
DOI: 10.2174/1389200222666210118101715
Abstract: BACKGROUND The role of multidrug resistance-associated protein 3 (Mrp3) in the transport of bile acid (BA) in drug-induced cholestasis have not been well studied. OBJECTIVE In this study, wild type and Mrp3 knockout (Mrp3-/- )… read more here.
Keywords: normal physiological; bile acids; mrp3; transport bile ... See more keywords