Abstract 420: Mrs2 is the Authentic Mammalian Mitochondrial Mg 2+ Channel
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DOI: 10.1161/res.127.suppl_1.420
Abstract: Magnesium (Mg 2+ ) is an important cation critical for cellular functions and tissue integrity. Mitochondria have been demonstrated to be capable of both accumulate and release Mg 2+ . However, the exact molecular machinery… read more here.
Keywords: mrs2 cells; mitochondrial channel; mrs2 authentic; channel ... See more keywords
The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity
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DOI: 10.26508/lsa.202201742
Abstract: Magnesium (Mg2+) binding to the human mitochondrial RNA splicing 2 (MRS2) protein channel amino terminal domain disrupts homomeric interactions and inhibits mitochondrial Mg2+ uptake as a negative feedback mechanism. Mitochondrial RNA splicing 2 (MRS2) forms… read more here.
Keywords: human mrs2; mg2; domain; mg2 binding ... See more keywords
Hepatocellular carcinoma subtypes based on metabolic pathways reveals potential therapeutic targets
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DOI: 10.3389/fonc.2023.1086604
Abstract: Introduction Hepatocellular carcinoma (HCC) is an aggressive malignancy with steadily increasing incidence rates worldwide and poor therapeutic outcomes. Studies show that metabolic reprogramming plays a key role in tumor genesis and progression. In this study,… read more here.
Keywords: cell; hepatocellular carcinoma; hcc; expression ... See more keywords