Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant Staphylococcus aureus (MRSA) Infection
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200036
Abstract: Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria‐activated single‐ and dual‐antibiotic… read more here.
Keywords: methicillin resistant; staphylococcus aureus; aureus mrsa; mrsa infection ... See more keywords
Infection Microenvironment-Sensitive Photothermal Nanotherapeutic Platform to Inhibit Methicillin-Resistant Staphylococcus aureus Infection.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200430
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) can induce multiple inflammations. The biofilm formed by MRSA is resistant to a variety of antibiotics and is extremely difficult to cure, which seriously threatens human health. Herein, a nanoparticle encapsulating… read more here.
Keywords: methicillin resistant; infection; staphylococcus aureus; biofilm ... See more keywords
Recent advances in Clp protease modulation to address virulence, resistance and persistence of MRSA infection.
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DOI: 10.1016/j.drudis.2021.05.014
Abstract: The caseinolytic protease (ClpP) is an AAA+ protease that executes abnormally folded or malfunctioning proteins, and has an important role in producing virulence factors, forming biofilms or persisters and developing methicillin-resistant Staphylococcus aureus (MRSA). Recent… read more here.
Keywords: mrsa infection; virulence; resistance; recent advances ... See more keywords
CP and CP-PGN protect mice against MRSA infection by inducing M1 macrophages
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DOI: 10.1038/s41598-017-17001-0
Abstract: Corynebacterium pyruviciproducens (C. pyruviciproducens, CP), as a newly discovered immunomodulator, has been confirmed to have a stronger immunoregulation than Propionibacterium acnes (P. acnes) of the traditional immune adjuvant, by previous experiments with model antigen ovalbumin… read more here.
Keywords: mrsa infection; infection; pgn protect; mrsa ... See more keywords
MRSA infection of masticatory spaces in a paediatric patient
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DOI: 10.1136/bcr-2020-236766
Abstract: Diagnosis of source of maxillofacial infection in paediatric patients can be challenging due to difficulty in eliciting a proper history and multiple potential sources of infection. Identification and removal of the nidus of infection with… read more here.
Keywords: paediatric patient; spaces paediatric; infection masticatory; mrsa infection ... See more keywords
Effect of MRSA on CYP450: dynamic changes of cytokines, oxidative stress, and drug-metabolizing enzymes in mice infected with MRSA
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DOI: 10.2147/idr.s153871
Abstract: Background Methicillin-resistant Staphylococcus aureus (MRSA) is a very damaging and widespread pathogen, which is associated with many diseases and causes serious infections. MRSA infection can modulate the effects of drugs, which may occur through an… read more here.
Keywords: drug; drug metabolizing; mrsa infection; oxidative stress ... See more keywords
MRSA Infection in the Thigh Muscle Leads to Systemic Disease, Strong Inflammation, and Loss of Human Monocytes in Humanized Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.892053
Abstract: MRSA (Methicillin-resistant Staphylococcus aureus) is the second-leading cause of deaths by antibiotic-resistant bacteria globally, with more than 100,000 attributable deaths annually. Despite the high urgency to develop a vaccine to control this pathogen, all clinical… read more here.
Keywords: humanized mice; thigh muscle; infection; mice ... See more keywords
T Cell Receptor Immune Repertoires Are Promptly Reconstituted After Methicillin-Resistant Staphylococcus aureus Infection
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02012
Abstract: T cells represent a subset of lymphocytes characterized by immunosurveillance and immunoregulation function. Peripheral blood mononuclear cells (PBMCs) are enriched in T cells, which exert critical antimicrobial roles in infectious diseases. High-throughput sequencing of the… read more here.
Keywords: mrsa infection; infection; resistant staphylococcus; cell receptor ... See more keywords
Novel copper-containing ferrite nanoparticles exert lethality to MRSA by disrupting MRSA cell membrane permeability, depleting intracellular iron ions, and upregulating ROS levels
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1023036
Abstract: Objective The widespread use of antibiotics has inevitably led to the emergence of multidrug-resistant bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA), making treatment of this infection a serious challenge. This study aimed to explore… read more here.
Keywords: cell; infection; copper containing; containing ferrite ... See more keywords