In Vitro Potency and Spectrum of the Novel Polymyxin MRX-8 Tested against Clinical Isolates of Gram-Negative Bacteria
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DOI: 10.1128/aac.00139-22
Abstract: The polymyxins display excellent in vitro antimicrobial activity against most Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii isolates, but their clinical utility has been limited because of class-specific toxicity problems. Therefore, new polymyxin analogs with improved… read more here.
Keywords: mrx; novel polymyxin; potency spectrum; polymyxin ... See more keywords
A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo
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DOI: 10.1128/aac.00601-22
Abstract: Therapeutic options for Mycobacterium abscessus infections are extremely limited, and new drugs are needed. The anti-M. abscessus activity of MRX-6038, ABSTRACT Therapeutic options for Mycobacterium abscessus infections are extremely limited, and new drugs are needed.… read more here.
Keywords: mrx 6038; mrx; mycobacterium abscessus; abscessus activity ... See more keywords