In Vitro Potency and Spectrum of the Novel Polymyxin MRX-8 Tested against Clinical Isolates of Gram-Negative Bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00139-22
Abstract: The polymyxins display excellent in vitro antimicrobial activity against most Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii isolates, but their clinical utility has been limited because of class-specific toxicity problems. Therefore, new polymyxin analogs with improved… read more here.
Keywords: mrx; novel polymyxin; potency spectrum; polymyxin ... See more keywords
A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo
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DOI: 10.1128/aac.00601-22
Abstract: Therapeutic options for Mycobacterium abscessus infections are extremely limited, and new drugs are needed. The anti-M. abscessus activity of MRX-6038, ABSTRACT Therapeutic options for Mycobacterium abscessus infections are extremely limited, and new drugs are needed.… read more here.
Keywords: mrx 6038; mrx; mycobacterium abscessus; abscessus activity ... See more keywords
Oral oxaborole MRX-5 exhibits efficacy against pulmonary Mycobacterium abscessus in mouse
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DOI: 10.1128/aac.01351-24
Abstract: ABSTRACT Mycobacterium abscessus (Mab) is an opportunistic pathogen common in patients with lung comorbidities and immunosuppression. There are no FDA-approved treatments, and current treatment has a failure rate exceeding 50%. The intravenous oxaborole MRX-6038 is… read more here.
Keywords: mrx; oral oxaborole; mycobacterium abscessus; oxaborole mrx ... See more keywords
Synergistic combination of next-generation polymyxin MRX-8 and meropenem against carbapenem-resistant A. baumannii
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DOI: 10.1128/aac.01912-24
Abstract: ABSTRACT MRX-8 is a new next-generation polymyxin with potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB). This study evaluated the MRX-8 and meropenem combination and their dosing regimens against CRAB in clinics. Seven CRAB strains… read more here.
Keywords: combination; mrx meropenem; mrx; continuous infusion ... See more keywords