Abstract 6201: Live biotherapeutic MRx0518 as a modulator of immune responses in intestinal tissue and breast tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6201
Abstract: Introduction: The human gut microbiota plays a role in modulating both intestinal and systemic immunity. Its importance in regulating anti-tumorigenic responses is now being explored, supported by evidence that the functional profile of the gut… read more here.
Keywords: microenvironment; tumor; live biotherapeutic; immune responses ... See more keywords
A phase I/II study of live biotherapeutic MRx0518 in combination with pembrolizumab in patients who have progressed on prior anti-PD-1 therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.tps2670
Abstract: TPS2670 Background: The gut microbiome has emerged as a new therapeutic target to augment the efficacy of immune checkpoint blockade. MRx0518 is a novel, gut microbiome-derived, oral live biotherapeutic, designed to induce a broad immunostimulatory… read more here.
Keywords: combination pembrolizumab; mrx0518 combination; oncology; mrx0518 ... See more keywords