The Aβ aggregation modulator MRZ-99030 prevents and even reverses synaptotoxic effects of Aβ1-42 on LTP even following serial dilution to a 500:1 stoichiometric excess of Aβ1-42, suggesting a beneficial prion-like seeding mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108267
Abstract: MRZ-99030 (GAL-101) is a small molecule that promotes the formation of off-pathway, non-toxic amorphous clusters of Aβ thereby reducing the amount of toxic soluble oligomeric Aβ species. MRZ-99030 clearly prevents synaptotoxic effects of Aβ1-42 oligomers… read more here.
Keywords: mrz 99030; mrz; synaptotoxic effects; stoichiometric excess ... See more keywords
Recognition of Machine-Readable Zone in Identity Documents: A Review
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DOI: 10.1109/access.2025.3571547
Abstract: Encoding personal identity document information into machine-readable formats is one of the most important approaches to automatic data processing. The Machine-Readable Zone (MRZ) of a document contains text data in the form of 2 or… read more here.
Keywords: mrz; recognition; identity; readable zone ... See more keywords
Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies
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DOI: 10.3390/ph18010046
Abstract: Background/Objectives: Mirtazapine (MRZ) is a psychotropic drug prescribed to manage serious sorts of depression. By virtue of its extensive initial-pass metabolic process with poor water solubility, the ultimate bioavailability when taken orally is a mere… read more here.
Keywords: mrz lpx; brain; mrz; delivery ... See more keywords