Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
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DOI: 10.1021/acs.jmedchem.2c00403
Abstract: The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-TEAD triggered gene transcription is an attractive strategy for therapeutic intervention. The deeply buried… read more here.
Keywords: msc 4106; site; binding fragment; optimization ... See more keywords