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   Articles with "msc evs" as a keyword



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The therapeutic capacity of bone marrow MSC‐derived extracellular vesicles in Achilles tendon healing is passage‐dependent and indicated by specific glycans

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14333

Abstract: The therapeutic potential of mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) for various diseases and tissue repair is attracting attention. Here, EVs from conditioned medium of human bone marrow MSCs at passage 5 (P5) and… read more here.

Keywords: tendon healing; achilles tendon; msc; msc evs ... See more keywords
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Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine.

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recommendations! Published in 2023 at "Advanced healthcare materials"

DOI: 10.1002/adhm.202202453

Abstract: Owing to the low immunogenicity and high target affinities, mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) have been considered promising therapeutics for disease treatments. However, MSC-EVs that are harvested from different tissues present unique biological features… read more here.

Keywords: msc evs; heterogeneity; medicine; stem stromal ... See more keywords
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First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles

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recommendations! Published in 2021 at "Journal of Extracellular Vesicles"

DOI: 10.1002/jev2.12094

Abstract: Abstract Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti‐inflammatory effects. MSC‐EVs may serve as promising cell‐based therapeutics for the inner ear… read more here.

Keywords: extracellular vesicles; intracochlear application; msc evs; evs ... See more keywords
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Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

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recommendations! Published in 2020 at "Stem Cells Translational Medicine"

DOI: 10.1002/sctm.19-0327

Abstract: Abstract The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down… read more here.

Keywords: neuroprotective effects; alzheimer disease; msc evs; mesenchymal stem ... See more keywords
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Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

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recommendations! Published in 2017 at "Journal of Controlled Release"

DOI: 10.1016/j.jconrel.2017.08.022

Abstract: &NA; Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are potential therapies for various diseases, but their angiogenic mechanisms of therapeutic efficacy remain unclear. Here, we describe how MSC‐EVs, activates VEGF receptors and downstream… read more here.

Keywords: extracellular vesicles; activates vegf; msc evs; msc ... See more keywords
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Increasing yield of msc-evs in scalable xeno-free manufacturing

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.03.433

Abstract: Background & Aim Extracellular vesicles (EVs) are increasingly being investigated as both drug delivery vehicles and as a cell-free therapy. EVs from mesenchymal stem/stromal cells (MSC-EVs), for example, have been shown to recapitulate many of… read more here.

Keywords: msc evs; activator; yield; collection ... See more keywords
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Comparison of msc-evs manufatured in 2D versus scalable 3D bioreactor systems

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.03.434

Abstract: Background & Aim There have been over 800 registered clinical trials using mesenchymal stem/stromal cells (MSCs) for therapeutic applications. Due to their potential as a key bioactive agent in regenerative medicine applications, MSC-derived extracellular vesicles… read more here.

Keywords: bioreactor; bioreactor systems; msc evs; cell ... See more keywords
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Strategies for scalable manufacturing and translation of MSC-derived extracellular vesicles.

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recommendations! Published in 2020 at "Stem cell research"

DOI: 10.1016/j.scr.2020.101978

Abstract: Mesenchymal Stem/Stromal Cells (MSCs) are a well-studied cellular therapy with many clinical trials over the last few decades to treat a range of therapeutic indications. Recently, extracellular vesicles secreted by MSCs (MSC-EVs) have been shown… read more here.

Keywords: extracellular vesicles; manufacturing translation; strategies scalable; scalable manufacturing ... See more keywords
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One-Minute Iodine Isotope Labeling Technology Enables Noninvasive Tracking and Quantification of Extracellular Vesicles in Tumor Lesions and Intact Animals.

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recommendations! Published in 2023 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.3c00299

Abstract: Real-time monitoring of the biological behavior of extracellular vesicles (EVs) in vivo is limited, which hinders its application in biomedicine and clinical translation. A noninvasive imaging strategy could provide us with useful information on EVs'… read more here.

Keywords: cell; extracellular vesicles; 124i msc; msc evs ... See more keywords
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy

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recommendations! Published in 2020 at "Immunological Investigations"

DOI: 10.1080/08820139.2020.1712416

Abstract: ABSTRACT In recent years, mesenchymal stem/stromal cells (MSCs) have widely been considered as therapeutic tools in basic researches and clinical trials. Accumulating evidence supports the idea that MSCs perform their therapeutic roles in paracrine manner… read more here.

Keywords: extracellular vesicles; cell derived; msc evs; stem cell ... See more keywords
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Immunomodulatory and regenerative effects of MSC-derived extracellular vesicles to treat acute GVHD.

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recommendations! Published in 2022 at "Stem cells"

DOI: 10.1093/stmcls/sxac057

Abstract: The development of human mesenchymal stromal/stem cell (MSC)-based therapy has focused on exploring biological nanoparticles secreted from MSCs. There is emerging evidence that the immunomodulatory and regenerative effects of MSCs can be recapitulated by extracellular… read more here.

Keywords: regenerative effects; extracellular vesicles; treat acute; msc evs ... See more keywords