MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.11.028
Abstract: Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing critical size osteochondral defects in an immunocompetent rat model. Here we investigate the cellular processes modulated by MSC exosomes and the mechanism… read more here.
Keywords: cartilage repair; msc exosomes; proliferation; exosome mediated ... See more keywords
MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.02.006
Abstract: The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC exosomes in the regulation of inflammatory response, nociceptive behaviour, and… read more here.
Keywords: joint osteoarthritis; inflammation; temporomandibular joint; msc exosomes ... See more keywords
Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.12.021
Abstract: Abstract Mesenchymal stem cells (MSCs) and regulatory T cells (Tregs) are both potent immune‐modulators. The aberrant proliferation and function of Tregs plays an important role in the development of asthma. Our previous studies have demonstrated… read more here.
Keywords: exosomes promote; regulatory cells; msc exosomes; proliferation ... See more keywords
Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Cytotherapy"
DOI: 10.1016/s1465324921004436
Abstract: Severe psoriasis, a chronic inflammatory skin disease is increasingly being effectively managed by targeted immunotherapy but long-term immunotherapy poses health risk and loss of response. Therefore, there is a need for alternative therapy strategies. Mesenchymal… read more here.
Keywords: stratum corneum; msc exosomes; topically applied; psoriasis ... See more keywords
MSC exosome works through a protein-based mechanism of action
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society Transactions"
DOI: 10.1042/bst20180079
Abstract: Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are secreted into the extracellular space when multivesicular bodies in the MSC fuse with the plasma membrane. However, the exosome is just one of… read more here.
Keywords: exosome works; msc exosome; protein based; msc exosomes ... See more keywords
Mesenchymal Stem Cells-derived Exosomes Ameliorate Lupus by Inducing M2 Macrophage Polarization and Regulatory T Cell Expansion in MRL/lpr Mice
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2055478
Abstract: ABSTRACT Previous studies have implicated that the transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) effectively alleviates systemic lupus erythematosus (SLE) primarily due to immunomodulatory effects. However, little is known about the role of… read more here.
Keywords: lpr mice; derived exosomes; mesenchymal stem; msc exosomes ... See more keywords
Mesenchymal Stromal Cell Exosomes Mediate M2-like Macrophage Polarization through CD73/Ecto-5′-Nucleotidase Activity
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051489
Abstract: Mesenchymal stem/stromal cell (MSC) exosomes have been shown to alleviate immune dysfunction and inflammation in preclinical animal models. This therapeutic effect is attributed, in part, to their ability to promote the polarization of anti-inflammatory M2-like… read more here.
Keywords: macrophage polarization; like macrophage; activity; msc exosomes ... See more keywords
Mesenchymal stem cell-derived exosomes are beneficial to suppressing inflammation and promoting autophagy in intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2023 at "Folia morphologica"
DOI: 10.5603/fm.a2023.0021
Abstract: Intervertebral disc degenerative diseases (IDDD) is one the main causes of lumbago, and its main pathological mechanism is intervertebral disc degeneration (IDD). In previous reports, mesenchymal stem cell (MSC)-exosomes can slow down or even reverse… read more here.
Keywords: inflammation; mesenchymal stem; disc degeneration; intervertebral disc ... See more keywords