Practical considerations in transforming MSC therapy for neurological diseases from cell to EV
Sign Up to like & getrecommendations! Published in 2021 at "Experimental neurology"
DOI: 10.1016/j.expneurol.2021.113953
Abstract: Cell-based therapy using Mesenchymal Stromal Cell (MSC) has generally been efficacious in treating a myriad of diseases in animal models and clinical trials. The rationale for MSC therapy was predicated on the potential of MSC… read more here.
Keywords: msc sevs; neurological diseases; msc; therapy ... See more keywords
Augmenting Intracellular Cargo Delivery of Extracellular Vesicles in Hypoxic Tissues through Inhibiting Hypoxia-Induced Endocytic Recycling.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c10351
Abstract: As mesenchymal stem-cell-derived small extracellular vesicles (MSC-sEVs) have been widely applied in treatment of degenerative diseases, it is essential to improve their cargo delivery efficiency in specific microenvironments of lesions. However, the interaction between the… read more here.
Keywords: msc sevs; endocytic recycling; hypoxia; delivery ... See more keywords
Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1083459
Abstract: Chronic non-healing wounds have posed a severe threat to patients mentally and physically. Behavior dysregulation of remaining cells at wound sites is recognized as the chief culprit to destroy healing process and hinders wound healing.… read more here.
Keywords: non healing; wound treatment; chronic non; msc sevs ... See more keywords
MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.888949
Abstract: Background Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been increasingly proved as promising immunomodulators against some autoimmune disorders. However, the possible effect and the underlying mechanism of MSC-sEVs in autoimmune dry eye have been… read more here.
Keywords: msc sevs; msc; mir 100; small extracellular ... See more keywords
MSC−sEV Treatment Polarizes Pro−Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098092
Abstract: Mesenchymal stem/stromal cell small extracellular vesicles (MSC−sEVs) have shown promise in treating a wide range of animal models of various human diseases, which has led to their consideration for clinical translation. However, the possibility of… read more here.
Keywords: msc sevs; pro fibrotic; msc sev; liver fibrosis ... See more keywords